Owen JS - Search Results

1

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.

Papaioannou I, Simons JP, Owen JS. Papaioannou I, et al. Among authors: owen js. Cardiol Res Pract. 2012;2012:148796. doi: 10.1155/2012/148796. Epub 2012 May 7. Cardiol Res Pract. 2012. PMID: 22645694 Free PMC article.

2

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts).

Tagalakis AD, Dickson JG, Owen JS, Simons JP. Tagalakis AD, et al. Among authors: owen js. J Mol Neurosci. 2005;25(1):95-103. doi: 10.1385/JMN:25:1:095. J Mol Neurosci. 2005. PMID: 15781970

3

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7).

Evans V, Foster H, Graham IR, Foster K, Athanasopoulos T, Simons JP, Dickson G, Owen JS. Evans V, et al. Among authors: owen js. Hum Gene Ther. 2008 Jun;19(6):569-78. doi: 10.1089/hum.2007.169. Hum Gene Ther. 2008. PMID: 18578629

4

Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice.

Osman E, Evans V, Graham IR, Athanasopoulos T, McIntosh J, Nathwani AC, Simons JP, Dickson G, Owen JS. Osman E, et al. Among authors: owen js. Atherosclerosis. 2009 May;204(1):121-6. doi: 10.1016/j.atherosclerosis.2008.08.043. Epub 2008 Sep 11. Atherosclerosis. 2009. PMID: 18930458

5

Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing.

Papaioannou I, Disterer P, Owen JS. Papaioannou I, et al. Among authors: owen js. J Gene Med. 2009 Mar;11(3):267-74. doi: 10.1002/jgm.1296. J Gene Med. 2009. PMID: 19153972

6

Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle.

Evans VC, Graham IR, Athanasopoulos T, Galley DJ, Jackson CL, Simons JP, Dickson G, Owen JS. Evans VC, et al. Among authors: owen js. Metabolism. 2011 Apr;60(4):491-8. doi: 10.1016/j.metabol.2010.04.015. Epub 2010 May 23. Metabolism. 2011. PMID: 20580777

7

Oligonucleotide-mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression.

Disterer P, Papaioannou I, Evans VC, Simons JP, Owen JS. Disterer P, et al. Among authors: owen js. J Gene Med. 2012 Feb;14(2):109-19. doi: 10.1002/jgm.1639. J Gene Med. 2012. PMID: 22228477

8

Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.

Papaioannou I, Simons JP, Owen JS. Papaioannou I, et al. Among authors: owen js. Expert Opin Biol Ther. 2012 Mar;12(3):329-42. doi: 10.1517/14712598.2012.660522. Epub 2012 Feb 10. Expert Opin Biol Ther. 2012. PMID: 22321001 Review.

9

Validation of oligonucleotide-mediated gene editing.

Disterer P, Simons JP, Owen JS. Disterer P, et al. Among authors: owen js. Gene Ther. 2009 Jun;16(6):824-6. doi: 10.1038/gt.2009.32. Epub 2009 Apr 2. Gene Ther. 2009. PMID: 19340016

10

Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo.

Disterer P, Al-Shawi R, Ellmerich S, Waddington SN, Owen JS, Simons JP, Khoo B. Disterer P, et al. Among authors: owen js. Mol Ther. 2013 Mar;21(3):602-9. doi: 10.1038/mt.2012.264. Epub 2013 Jan 15. Mol Ther. 2013. PMID: 23319054 Free PMC article.

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