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Page 1
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP. Latypov VF, et al. Among authors: mcgown g. Mol Cell. 2012 Jul 13;47(1):50-60. doi: 10.1016/j.molcel.2012.04.028. Epub 2012 May 31. Mol Cell. 2012. PMID: 22658721 Free PMC article.
Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells.
Margison GP, Heighway J, Pearson S, McGown G, Thorncroft MR, Watson AJ, Harrison KL, Lewis SJ, Rohde K, Barber PV, O'Donnell P, Povey AC, Santibáñez-Koref MF. Margison GP, et al. Among authors: mcgown g. Carcinogenesis. 2005 Aug;26(8):1473-80. doi: 10.1093/carcin/bgi087. Epub 2005 Apr 14. Carcinogenesis. 2005. PMID: 15831531
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, Kroeger MD, Peterson LA, Williams DM, Fried MG, Margison GP, Pegg AE, Tainer JA. Tubbs JL, et al. Among authors: mcgown g. Nature. 2009 Jun 11;459(7248):808-13. doi: 10.1038/nature08076. Nature. 2009. PMID: 19516334 Free PMC article.
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
Wilkinson OJ, Latypov V, Tubbs JL, Millington CL, Morita R, Blackburn H, Marriott A, McGown G, Thorncroft M, Watson AJ, Connolly BA, Grasby JA, Masui R, Hunter CA, Tainer JA, Margison GP, Williams DM. Wilkinson OJ, et al. Among authors: mcgown g. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18755-60. doi: 10.1073/pnas.1209451109. Epub 2012 Oct 29. Proc Natl Acad Sci U S A. 2012. PMID: 23112169 Free PMC article.
Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib.
Watson AJ, Sabharwal A, Thorncroft M, McGown G, Kerr R, Bojanic S, Soonawalla Z, King A, Miller A, Waller S, Leung H, Margison GP, Middleton MR. Watson AJ, et al. Among authors: mcgown g. Clin Cancer Res. 2010 Jan 15;16(2):743-9. doi: 10.1158/1078-0432.CCR-09-1389. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068091 Free PMC article. Clinical Trial.
O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.
Watson AJ, Middleton MR, McGown G, Thorncroft M, Ranson M, Hersey P, McArthur G, Davis ID, Thomson D, Beith J, Haydon A, Kefford R, Lorigan P, Mortimer P, Sabharwal A, Hayward O, Margison GP. Watson AJ, et al. Among authors: mcgown g. Br J Cancer. 2009 Apr 21;100(8):1250-6. doi: 10.1038/sj.bjc.6605015. Br J Cancer. 2009. PMID: 19367283 Free PMC article. Clinical Trial.
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Plummer ER, et al. Among authors: mcgown g. Clin Cancer Res. 2005 May 1;11(9):3402-9. doi: 10.1158/1078-0432.CCR-04-2353. Clin Cancer Res. 2005. PMID: 15867241 Free article. Clinical Trial.
Thirteen dinucleotide repeat polymorphisms on chromosome 6.
Orphanos V, McGown G, Boyle JM, Santibanez-Koref M. Orphanos V, et al. Among authors: mcgown g. Hum Mol Genet. 1993 Dec;2(12):2196. doi: 10.1093/hmg/2.12.2196. Hum Mol Genet. 1993. PMID: 8111393 No abstract available.
27 results