Park BK - Search Results

1

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Copple IM, Mercer AE, Firman J, Donegan G, Herpers B, Wong MH, Chadwick J, Bringela AD, Cristiano ML, van de Water B, Ward SA, O'Neill PM, Park BK. Copple IM, et al. Among authors: park bk. Mol Med. 2012 Sep 25;18(1):1045-55. doi: 10.2119/molmed.2012.00154. Mol Med. 2012. PMID: 22669474 Free PMC article.

2

The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Mercer AE, Copple IM, Maggs JL, O'Neill PM, Park BK. Mercer AE, et al. Among authors: park bk. J Biol Chem. 2011 Jan 14;286(2):987-96. doi: 10.1074/jbc.M110.144188. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059641 Free PMC article.

3

Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds.

Mercer AE, Maggs JL, Sun XM, Cohen GM, Chadwick J, O'Neill PM, Park BK. Mercer AE, et al. Among authors: park bk. J Biol Chem. 2007 Mar 30;282(13):9372-9382. doi: 10.1074/jbc.M610375200. Epub 2007 Jan 16. J Biol Chem. 2007. PMID: 17227762 Free article.

4

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

Chadwick J, Mercer AE, Park BK, Cosstick R, O'Neill PM. Chadwick J, et al. Among authors: park bk. Bioorg Med Chem. 2009 Feb 1;17(3):1325-38. doi: 10.1016/j.bmc.2008.12.017. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19136263

5

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

Jones M, Mercer AE, Stocks PA, La Pensée LJ, Cosstick R, Park BK, Kennedy ME, Piantanida I, Ward SA, Davies J, Bray PG, Rawe SL, Baird J, Charidza T, Janneh O, O'Neill PM. Jones M, et al. Among authors: park bk. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2033-7. doi: 10.1016/j.bmcl.2009.02.028. Epub 2009 Feb 11. Bioorg Med Chem Lett. 2009. PMID: 19249201 Free article.

6

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

Chadwick J, Jones M, Mercer AE, Stocks PA, Ward SA, Park BK, O'Neill PM. Chadwick J, et al. Among authors: park bk. Bioorg Med Chem. 2010 Apr 1;18(7):2586-97. doi: 10.1016/j.bmc.2010.02.035. Epub 2010 Feb 23. Bioorg Med Chem. 2010. PMID: 20227283

7

Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.

Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM. Bousejra-El Garah F, et al. Among authors: park bk. J Med Chem. 2011 Oct 13;54(19):6443-55. doi: 10.1021/jm200768h. Epub 2011 Sep 19. J Med Chem. 2011. PMID: 21888440

8

Role of Nrf2 in protection against acute kidney injury.

Shelton LM, Park BK, Copple IM. Shelton LM, et al. Among authors: park bk. Kidney Int. 2013 Dec;84(6):1090-5. doi: 10.1038/ki.2013.248. Epub 2013 Jun 19. Kidney Int. 2013. PMID: 23783243 Free article. Review.

9

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress.

Mutter FE, Park BK, Copple IM. Mutter FE, et al. Among authors: park bk. Biochem Soc Trans. 2015 Aug;43(4):657-62. doi: 10.1042/BST20150044. Epub 2015 Aug 3. Biochem Soc Trans. 2015. PMID: 26551708 Free PMC article. Review.

10

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. Hawley SR, et al. Among authors: park bk. Biochem Pharmacol. 1996 Sep 13;52(5):723-33. doi: 10.1016/0006-2952(96)00354-1. Biochem Pharmacol. 1996. PMID: 8765470

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