Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.
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Ceccaldi R, et al. Among authors: gluckman e.
Cell Stem Cell. 2012 Jul 6;11(1):36-49. doi: 10.1016/j.stem.2012.05.013. Epub 2012 Jun 7.
Cell Stem Cell. 2012.
PMID: 22683204
Free PMC article.