Hu YH - Search Results

1

A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis.

Fang JP, Liu Y, Li J, Liao WF, Hu YH, Ding K. Fang JP, et al. Among authors: hu yh. Acta Pharmacol Sin. 2012 Sep;33(9):1204-16. doi: 10.1038/aps.2012.56. Epub 2012 Jun 11. Acta Pharmacol Sin. 2012. PMID: 22684031 Free PMC article.

2

Base-promoted one-pot tandem reaction of 3-(1-alkynyl)chromones under microwave irradiation to functionalized amino-substituted xanthones.

Liu Y, Huang L, Xie F, Hu Y. Liu Y, et al. J Org Chem. 2010 Sep 17;75(18):6304-7. doi: 10.1021/jo1013614. J Org Chem. 2010. PMID: 20738144

3

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice.

Zhang XD, Yan JW, Yan GR, Sun XY, Ji J, Li YM, Hu YH, Wang HY. Zhang XD, et al. Among authors: hu yh. Acta Pharmacol Sin. 2010 Nov;31(11):1470-7. doi: 10.1038/aps.2010.104. Acta Pharmacol Sin. 2010. PMID: 21052084 Free PMC article.

4

Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations.

Liu Y, Huang L, Xie F, Chen X, Hu Y. Liu Y, et al. Org Biomol Chem. 2011 Apr 21;9(8):2680-4. doi: 10.1039/c0ob01000f. Epub 2011 Mar 2. Org Biomol Chem. 2011. PMID: 21369579

5

Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors.

Liu Y, Fang J, Cai H, Xiao F, Ding K, Hu Y. Liu Y, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5473-82. doi: 10.1016/j.bmc.2012.07.035. Epub 2012 Jul 28. Bioorg Med Chem. 2012. PMID: 22898255

6

An organic molecule modulated chemoselective cyclization of alkynyl nitriles tethered to 2-alkyl substituted chromones with multireactive sites.

Huang L, Liu Y, Xie F, Hu Y. Huang L, et al. Org Lett. 2012 Dec 21;14(24):6122-5. doi: 10.1021/ol302964x. Epub 2012 Dec 4. Org Lett. 2012. PMID: 23210678

7

Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells.

He CX, Ai J, Xing WQ, Chen Y, Zhang HT, Huang M, Hu YH, Ding J, Geng MY. He CX, et al. Among authors: hu yh. Acta Pharmacol Sin. 2014 Jan;35(1):89-97. doi: 10.1038/aps.2013.125. Epub 2013 Nov 18. Acta Pharmacol Sin. 2014. PMID: 24241352 Free PMC article.

8

Microwave assisted tandem Heck-Sonogashira reactions of N,N-di-Boc-protected 6-amino-5-iodo-2-methyl pyrimidin-4-ol in an efficient approach to functionalized pyrido[2,3-d]pyrimidines.

Liu Y, Jin S, Wang Z, Song L, Hu Y. Liu Y, et al. Org Lett. 2014 Jul 3;16(13):3524-7. doi: 10.1021/ol501459e. Epub 2014 Jun 23. Org Lett. 2014. PMID: 24956126

9

Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease.

Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. Yu Y, et al. Among authors: hu yh. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. doi: 10.1038/aps.2014.55. Epub 2014 Jul 21. Acta Pharmacol Sin. 2014. PMID: 25066323 Free PMC article.

10

Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice.

Zeng HL, Huang SL, Xie FC, Zeng LM, Hu YH, Leng Y. Zeng HL, et al. Among authors: hu yh. Acta Pharmacol Sin. 2015 Mar;36(3):343-52. doi: 10.1038/aps.2014.147. Acta Pharmacol Sin. 2015. PMID: 25732571 Free PMC article.

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