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The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. Khalaf O, et al. Among authors: ruggeri fs. J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936070 Free PMC article.
Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.
Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA. Chiki A, et al. Among authors: ruggeri fs. Angew Chem Int Ed Engl. 2017 May 2;56(19):5202-5207. doi: 10.1002/anie.201611750. Epub 2017 Mar 23. Angew Chem Int Ed Engl. 2017. PMID: 28334491
75 results