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Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.
Yamanokuchi R, Imada K, Miyazaki M, Kato H, Watanabe T, Fujimuro M, Saeki Y, Yoshinaga S, Terasawa H, Iwasaki N, Rotinsulu H, Losung F, Mangindaan RE, Namikoshi M, de Voogd NJ, Yokosawa H, Tsukamoto S. Yamanokuchi R, et al. Among authors: rotinsulu h. Bioorg Med Chem. 2012 Jul 15;20(14):4437-42. doi: 10.1016/j.bmc.2012.05.044. Epub 2012 May 24. Bioorg Med Chem. 2012. PMID: 22695182
Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.
Nagasawa Y, Ueoka R, Yamanokuchi R, Horiuchi N, Ikeda T, Rotinsulu H, Mangindaan RE, Ukai K, Kobayashi H, Namikoshi M, Hirota H, Yokosawa H, Tsukamoto S. Nagasawa Y, et al. Among authors: rotinsulu h. Chem Pharm Bull (Tokyo). 2011;59(2):287-90. doi: 10.1248/cpb.59.287. Chem Pharm Bull (Tokyo). 2011. PMID: 21297314 Free article.
Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.
Eguchi K, Fujiwara Y, Hayashida A, Horlad H, Kato H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S. Eguchi K, et al. Among authors: rotinsulu h. Bioorg Med Chem. 2013 Jul 1;21(13):3831-8. doi: 10.1016/j.bmc.2013.04.025. Epub 2013 Apr 21. Bioorg Med Chem. 2013. PMID: 23665143
Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.
Yamazaki H, Nakayama W, Takahashi O, Kirikoshi R, Izumikawa Y, Iwasaki K, Toraiwa K, Ukai K, Rotinsulu H, Wewengkang DS, Sumilat DA, Mangindaan RE, Namikoshi M. Yamazaki H, et al. Among authors: rotinsulu h. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3087-90. doi: 10.1016/j.bmcl.2015.06.026. Epub 2015 Jun 14. Bioorg Med Chem Lett. 2015. PMID: 26115570
34 results