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Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.
Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E. Bourguignon LY, et al. J Biol Chem. 2009 Sep 25;284(39):26533-46. doi: 10.1074/jbc.M109.027466. Epub 2009 Jul 24. J Biol Chem. 2009. PMID: 19633292 Free PMC article.
Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFκB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion.
Bourguignon LY, Wong G, Earle CA, Xia W. Bourguignon LY, et al. Cytoskeleton (Hoboken). 2011 Dec;68(12):671-93. doi: 10.1002/cm.20544. Epub 2011 Nov 29. Cytoskeleton (Hoboken). 2011. PMID: 22031535 Free PMC article.
143 results