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The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.
Hebner CM, Han B, Brendza KM, Nash M, Sulfab M, Tian Y, Hung M, Fung W, Vivian RW, Trenkle J, Taylor J, Bjornson K, Bondy S, Liu X, Link J, Neyts J, Sakowicz R, Zhong W, Tang H, Schmitz U. Hebner CM, et al. Among authors: fung w. PLoS One. 2012;7(6):e39163. doi: 10.1371/journal.pone.0039163. Epub 2012 Jun 13. PLoS One. 2012. PMID: 22720059 Free PMC article.
Lipid-sensing high-throughput ApoA-I assays.
Niedziela-Majka A, Lad L, Chisholm JW, Lagpacan L, Schwartz K, Hung M, Jin D, Fung W, Brendza KM, Liu X, Pagratis N, Sakowicz R. Niedziela-Majka A, et al. Among authors: fung w. J Biomol Screen. 2012 Sep;17(8):1050-61. doi: 10.1177/1087057112451923. Epub 2012 Jul 17. J Biomol Screen. 2012. PMID: 22811478
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Sperandio D, Aktoudianakis V, Babaoglu K, Chen X, Elbel K, Chin G, Corkey B, Du J, Jiang B, Kobayashi T, Mackman R, Martinez R, Yang H, Zablocki J, Kusam S, Jordan K, Webb H, Bates JG, Lad L, Mish M, Niedziela-Majka A, Metobo S, Sapre A, Hung M, Jin D, Fung W, Kan E, Eisenberg G, Larson N, Newby ZER, Lansdon E, Tay C, Neve RM, Shevick SL, Breckenridge DG. Sperandio D, et al. Among authors: fung w. Bioorg Med Chem. 2019 Feb 1;27(3):457-469. doi: 10.1016/j.bmc.2018.11.020. Epub 2018 Nov 15. Bioorg Med Chem. 2019. PMID: 30606676
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
Blomgren P, Chandrasekhar J, Di Paolo JA, Fung W, Geng G, Ip C, Jones R, Kropf JE, Lansdon EB, Lee S, Lo JR, Mitchell SA, Murray B, Pohlmeyer C, Schmitt A, Suekawa-Pirrone K, Wise S, Xiong JM, Xu J, Yu H, Zhao Z, Currie KS. Blomgren P, et al. Among authors: fung w. ACS Med Chem Lett. 2020 Feb 12;11(4):506-513. doi: 10.1021/acsmedchemlett.9b00621. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292557 Free PMC article.
Mind the gap in kidney care: translating what we know into what we do.
Luyckx VA, Tuttle KR, Abdellatif D, Correa-Rotter R, Fung WWS, Haris A, Hsiao LL, Khalife M, Kumaraswami LA, Loud F, Raghavan V, Roumeliotis S, Sierra M, Ulasi I, Wang B, Lui SF, Liakopoulos V, Balducci A; World Kidney Day Joint Steering Committee. Luyckx VA, et al. Among authors: fung wws. Kidney Res Clin Pract. 2025 Jan 15. doi: 10.23876/j.krcp.24.100. Online ahead of print. Kidney Res Clin Pract. 2025. PMID: 39815796 Free article.
Mind the gap in kidney care: Translating what we know into what we do.
Luyckx VA, Tuttle KR, Abdellatif D, Correa-Rotter R, Fung WWS, Haris A, Hsiao LL, Khalife M, Kumaraswami LA, Loud F, Raghavan V, Roumeliotis S, Sierra M, Ulasi I, Wang B, Lui SF, Liakopoulos V, Balducci A; World Kidney Day Joint Steering Committee. Luyckx VA, et al. Among authors: fung wws. Nephrology (Carlton). 2025 Jan;30(1):e14314. doi: 10.1111/nep.14314. Nephrology (Carlton). 2025. PMID: 39789717 Free PMC article.
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction.
Hansen CE, Vacondio D, van der Molen L, Jüttner AA, Fung WK, Karsten M, van Het Hof B, Fontijn RD, Kooij G, Witte ME, Roks AJM, de Vries HE, Mulder I, de Wit NM. Hansen CE, et al. Among authors: fung wk. Cell Death Dis. 2025 Jan 3;16(1):1. doi: 10.1038/s41419-024-07306-0. Cell Death Dis. 2025. PMID: 39753531 Free PMC article.
556 results