Hung M - Search Results

1

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function.

Hebner CM, Han B, Brendza KM, Nash M, Sulfab M, Tian Y, Hung M, Fung W, Vivian RW, Trenkle J, Taylor J, Bjornson K, Bondy S, Liu X, Link J, Neyts J, Sakowicz R, Zhong W, Tang H, Schmitz U. Hebner CM, et al. Among authors: hung m. PLoS One. 2012;7(6):e39163. doi: 10.1371/journal.pone.0039163. Epub 2012 Jun 13. PLoS One. 2012. PMID: 22720059 Free PMC article.

2

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Yu F, Jones GS, Hung M, Wagner AH, MacArthur HL, Liu X, Leavitt S, McDermott MJ, Tsiang M. Yu F, et al. Among authors: hung m. Biochemistry. 2007 Mar 13;46(10):2899-908. doi: 10.1021/bi602387u. Epub 2007 Feb 14. Biochemistry. 2007. PMID: 17298035

3

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.

Tsiang M, Jones GS, Hung M, Mukund S, Han B, Liu X, Babaoglu K, Lansdon E, Chen X, Todd J, Cai T, Pagratis N, Sakowicz R, Geleziunas R. Tsiang M, et al. Among authors: hung m. J Biol Chem. 2009 Nov 27;284(48):33580-99. doi: 10.1074/jbc.M109.040121. Epub 2009 Sep 28. J Biol Chem. 2009. PMID: 19801648 Free PMC article.

4

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

Lansdon EB, Samuel D, Lagpacan L, Brendza KM, White KL, Hung M, Liu X, Boojamra CG, Mackman RL, Cihlar T, Ray AS, McGrath ME, Swaminathan S. Lansdon EB, et al. Among authors: hung m. J Mol Biol. 2010 Apr 9;397(4):967-78. doi: 10.1016/j.jmb.2010.02.019. Epub 2010 Feb 13. J Mol Biol. 2010. PMID: 20156454

5

Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.

Lansdon EB, Brendza KM, Hung M, Wang R, Mukund S, Jin D, Birkus G, Kutty N, Liu X. Lansdon EB, et al. Among authors: hung m. J Med Chem. 2010 May 27;53(10):4295-9. doi: 10.1021/jm1002233. J Med Chem. 2010. PMID: 20438081

6

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.

Khaki AR, Field C, Malik S, Niedziela-Majka A, Leavitt SA, Wang R, Hung M, Sakowicz R, Brendza KM, Fischer CJ. Khaki AR, et al. Among authors: hung m. J Mol Biol. 2010 Jul 16;400(3):354-78. doi: 10.1016/j.jmb.2010.04.065. Epub 2010 May 6. J Mol Biol. 2010. PMID: 20451531 Free PMC article.

7

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.

Tsiang M, Jones GS, Hung M, Samuel D, Novikov N, Mukund S, Brendza KM, Niedziela-Majka A, Jin D, Liu X, Mitchell M, Sakowicz R, Geleziunas R. Tsiang M, et al. Among authors: hung m. Biochemistry. 2011 Mar 15;50(10):1567-81. doi: 10.1021/bi101504w. Epub 2011 Feb 21. Biochemistry. 2011. PMID: 21222490

8

Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor.

Huynh QK, Wise SJ, Koch KA, Castonguay LA, Reid BG, Pagratis EE, Koditek D, Glascock CB, Pitts KR, Turner BA, Liu X, Hung M, Han B, Pagratis N. Huynh QK, et al. Among authors: hung m. J Biomol Screen. 2011 Aug;16(7):724-33. doi: 10.1177/1087057111405846. Epub 2011 Apr 26. J Biomol Screen. 2011. PMID: 21521800

9

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery.

Hung M, Wang R, Liu X. Hung M, et al. Curr Protoc Pharmacol. 2011 Sep;Chapter 13:Unit13B.6. doi: 10.1002/0471141755.ph13b06s54. Curr Protoc Pharmacol. 2011. PMID: 21898331

10

New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.

Tsiang M, Jones GS, Niedziela-Majka A, Kan E, Lansdon EB, Huang W, Hung M, Samuel D, Novikov N, Xu Y, Mitchell M, Guo H, Babaoglu K, Liu X, Geleziunas R, Sakowicz R. Tsiang M, et al. Among authors: hung m. J Biol Chem. 2012 Jun 15;287(25):21189-203. doi: 10.1074/jbc.M112.347534. Epub 2012 Apr 25. J Biol Chem. 2012. PMID: 22535962 Free PMC article.

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