Witcher DR - Search Results

1

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH. Marriott HM, et al. Among authors: witcher dr. Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26. Thorax. 2012. PMID: 22735687 Free PMC article.

2

Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT.

Wroblewski VJ, Witcher DR, Becker GW, Davis KA, Dou S, Micanovic R, Newton CM, Noblitt TW, Richardson JM, Song HY, Hale JE. Wroblewski VJ, et al. Among authors: witcher dr. Biochem Pharmacol. 2003 Feb 15;65(4):657-67. doi: 10.1016/s0006-2952(02)01612-x. Biochem Pharmacol. 2003. PMID: 12566095

3

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Wroblewski VJ, McCloud C, Davis K, Manetta J, Micanovic R, Witcher DR. Wroblewski VJ, et al. Among authors: witcher dr. Drug Metab Dispos. 2003 Apr;31(4):502-7. doi: 10.1124/dmd.31.4.502. Drug Metab Dispos. 2003. PMID: 12642478

4

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ. Datta-Mannan A, et al. Among authors: witcher dr. Drug Metab Dispos. 2007 Jan;35(1):86-94. doi: 10.1124/dmd.106.011734. Epub 2006 Oct 18. Drug Metab Dispos. 2007. PMID: 17050651

5

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.

Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: witcher dr. J Biol Chem. 2007 Jan 19;282(3):1709-17. doi: 10.1074/jbc.M607161200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17135257 Free article.

6

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: witcher dr. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.

7

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.

Datta-Mannan A, Lu J, Witcher DR, Leung D, Tang Y, Wroblewski VJ. Datta-Mannan A, et al. Among authors: witcher dr. MAbs. 2015;7(6):1084-93. doi: 10.1080/19420862.2015.1075109. Epub 2015 Sep 4. MAbs. 2015. PMID: 26337808 Free PMC article.

8

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry.

Murphy AT, Witcher DR, Luan P, Wroblewski VJ. Murphy AT, et al. Among authors: witcher dr. Blood. 2007 Aug 1;110(3):1048-54. doi: 10.1182/blood-2006-11-057471. Epub 2007 Apr 13. Blood. 2007. PMID: 17435114 Free article.

9

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

Datta-Mannan A, Thangaraju A, Leung D, Tang Y, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: witcher dr. MAbs. 2015;7(3):483-93. doi: 10.1080/19420862.2015.1016696. MAbs. 2015. PMID: 25695748 Free PMC article.

10

Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human.

Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK. Kovalova N, et al. Among authors: witcher dr. Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10. Biopharm Drug Dispos. 2020. PMID: 32080869

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

56 results

Search Page

Filters