Ritschel T - Search Results

1

From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters.

Barandun LJ, Immekus F, Kohler PC, Tonazzi S, Wagner B, Wendelspiess S, Ritschel T, Heine A, Kansy M, Klebe G, Diederich F. Barandun LJ, et al. Among authors: ritschel t. Chemistry. 2012 Jul 23;18(30):9246-57. doi: 10.1002/chem.201200809. Epub 2012 Jun 26. Chemistry. 2012. PMID: 22736391

2

Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding.

Hörtner SR, Ritschel T, Stengl B, Kramer C, Schweizer WB, Wagner B, Kansy M, Klebe G, Diederich F. Hörtner SR, et al. Among authors: ritschel t. Angew Chem Int Ed Engl. 2007;46(43):8266-9. doi: 10.1002/anie.200702961. Angew Chem Int Ed Engl. 2007. PMID: 17902085 No abstract available.

3

High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.

Kohler PC, Ritschel T, Schweizer WB, Klebe G, Diederich F. Kohler PC, et al. Among authors: ritschel t. Chemistry. 2009 Oct 19;15(41):10809-17. doi: 10.1002/chem.200901270. Chemistry. 2009. PMID: 19746363

4

How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.

Ritschel T, Kohler PC, Neudert G, Heine A, Diederich F, Klebe G. Ritschel T, et al. ChemMedChem. 2009 Dec;4(12):2012-23. doi: 10.1002/cmdc.200900343. ChemMedChem. 2009. PMID: 19894214

5

High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.

Barandun LJ, Immekus F, Kohler PC, Ritschel T, Heine A, Orlando P, Klebe G, Diederich F. Barandun LJ, et al. Among authors: ritschel t. Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1798-807. doi: 10.1107/S0907444913014509. Epub 2013 Aug 17. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23999303

6

Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.

Ritschel T, Hoertner S, Heine A, Diederich F, Klebe G. Ritschel T, et al. Chembiochem. 2009 Mar 2;10(4):716-27. doi: 10.1002/cbic.200800782. Chembiochem. 2009. PMID: 19199329

7

An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction.

Ritschel T, Atmanene C, Reuter K, Van Dorsselaer A, Sanglier-Cianferani S, Klebe G. Ritschel T, et al. J Mol Biol. 2009 Nov 6;393(4):833-47. doi: 10.1016/j.jmb.2009.07.040. Epub 2009 Jul 21. J Mol Biol. 2009. PMID: 19627989

8

Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor.

van de Schans MG, Ritschel T, Bovee TF, Sanders MG, de Waard P, Gruppen H, Vincken JP. van de Schans MG, et al. Among authors: ritschel t. Chembiochem. 2015 Dec;16(18):2668-77. doi: 10.1002/cbic.201500343. Epub 2015 Nov 4. Chembiochem. 2015. PMID: 26449282

9

Influence of azide incorporation on binding affinity by small papain inhibitors.

Wammes AE, Hendriks TG, Amatdjais-Groenen HI, Wijdeven MA, van Hest JC, van Delft FL, Ritschel T, Rutjes FP. Wammes AE, et al. Among authors: ritschel t. Bioorg Med Chem. 2014 Oct 15;22(20):5593-603. doi: 10.1016/j.bmc.2014.06.001. Epub 2014 Jun 11. Bioorg Med Chem. 2014. PMID: 24972724

10

Snooker structure-based pharmacophore model explains differences in agonist and blocker binding to bitter receptor hTAS2R39.

Roland WS, Sanders MP, van Buren L, Gouka RJ, Gruppen H, Vincken JP, Ritschel T. Roland WS, et al. Among authors: ritschel t. PLoS One. 2015 Mar 2;10(3):e0118200. doi: 10.1371/journal.pone.0118200. eCollection 2015. PLoS One. 2015. PMID: 25729848 Free PMC article.

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