Bohn LM - Search Results

1

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, Heynen-Genel S, Mangravita-Novo A, Vicchiarelli M, Smith LH, Streicher JM, Caron MG, Barak LS, Bohn LM, Chung TD, Aubé J. Frankowski KJ, et al. Among authors: bohn lm. ACS Chem Neurosci. 2012 Mar 21;3(3):221-236. doi: 10.1021/cn200128x. Epub 2012 Jan 20. ACS Chem Neurosci. 2012. PMID: 22737280 Free PMC article.

2

Potentiated opioid analgesia in norepinephrine transporter knock-out mice.

Bohn LM, Xu F, Gainetdinov RR, Caron MG. Bohn LM, et al. J Neurosci. 2000 Dec 15;20(24):9040-5. doi: 10.1523/JNEUROSCI.20-24-09040.2000. J Neurosci. 2000. PMID: 11124980 Free PMC article.

3

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.

Bohn LM, Lefkowitz RJ, Caron MG. Bohn LM, et al. J Neurosci. 2002 Dec 1;22(23):10494-500. doi: 10.1523/JNEUROSCI.22-23-10494.2002. J Neurosci. 2002. PMID: 12451149 Free PMC article.

4

G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice.

Bohn LM, Gainetdinov RR, Caron MG. Bohn LM, et al. Neuromolecular Med. 2004;5(1):41-50. doi: 10.1385/NMM:5:1:041. Neuromolecular Med. 2004. PMID: 15001811 Review.

5

Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.

Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS. Bohn LM, et al. Mol Pharmacol. 2004 Jul;66(1):106-12. doi: 10.1124/mol.66.1.106. Mol Pharmacol. 2004. PMID: 15213301

6

Desensitization of G protein-coupled receptors and neuronal functions.

Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Gainetdinov RR, et al. Among authors: bohn lm. Annu Rev Neurosci. 2004;27:107-44. doi: 10.1146/annurev.neuro.27.070203.144206. Annu Rev Neurosci. 2004. PMID: 15217328 Review.

7

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization.

Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. Groer CE, et al. Among authors: bohn lm. Mol Pharmacol. 2007 Feb;71(2):549-57. doi: 10.1124/mol.106.028258. Epub 2006 Nov 7. Mol Pharmacol. 2007. PMID: 17090705 Free PMC article.

8

Herkinorin analogues with differential beta-arrestin-2 interactions.

Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Tidgewell K, et al. Among authors: bohn lm. J Med Chem. 2008 Apr 24;51(8):2421-31. doi: 10.1021/jm701162g. Epub 2008 Apr 2. J Med Chem. 2008. PMID: 18380425 Free PMC article.

9

Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain.

Tarselli MA, Raehal KM, Brasher AK, Streicher JM, Groer CE, Cameron MD, Bohn LM, Micalizio GC. Tarselli MA, et al. Among authors: bohn lm. Nat Chem. 2011 Jun;3(6):449-53. doi: 10.1038/nchem.1050. Nat Chem. 2011. PMID: 21602859

10

Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology: from a symposium on new concepts in mu-opioid pharmacology.

Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE. Lamb K, et al. Among authors: bohn lm. Drug Alcohol Depend. 2012 Mar 1;121(3):181-8. doi: 10.1016/j.drugalcdep.2011.10.026. Epub 2011 Nov 26. Drug Alcohol Depend. 2012. PMID: 22119134 Free PMC article.

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