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Page 1
Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.
Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Hartsel JA, et al. Among authors: mutunga jm. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22738634 Free PMC article.
Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.
Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR. Wong DM, et al. Among authors: mutunga jm. Chem Biol Interact. 2013 Mar 25;203(1):314-8. doi: 10.1016/j.cbi.2012.09.001. Epub 2012 Sep 16. Chem Biol Interact. 2013. PMID: 22989775 Free PMC article.
Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).
Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, Carlier PR. Wong DM, et al. Among authors: mutunga jm. PLoS One. 2012;7(10):e46712. doi: 10.1371/journal.pone.0046712. Epub 2012 Oct 1. PLoS One. 2012. PMID: 23049714 Free PMC article.
3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.
Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Verma A, et al. Among authors: mutunga jm. Bioorg Med Chem. 2015 Mar 15;23(6):1321-40. doi: 10.1016/j.bmc.2015.01.026. Epub 2015 Jan 22. Bioorg Med Chem. 2015. PMID: 25684426 Free PMC article.
Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae.
Mutunga JM, Anderson TD, Craft DT, Gross AD, Swale DR, Tong F, Wong DM, Carlier PR, Bloomquist JR. Mutunga JM, et al. Pestic Biochem Physiol. 2015 Jun;121:116-21. doi: 10.1016/j.pestbp.2015.03.001. Epub 2015 Mar 9. Pestic Biochem Physiol. 2015. PMID: 26047119 Free PMC article.
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Camerino E, Wong DM, Tong F, Körber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR. Camerino E, et al. Among authors: mutunga jm. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4405-11. doi: 10.1016/j.bmcl.2015.09.019. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26386602 Free PMC article.
Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.
Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Müller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR. Carlier PR, et al. Among authors: mutunga jm. Pestic Biochem Physiol. 2018 Oct;151:32-39. doi: 10.1016/j.pestbp.2018.02.003. Epub 2018 Feb 13. Pestic Biochem Physiol. 2018. PMID: 30524149 Free PMC article.
29 results