Lecka J - Search Results

1

Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors.

Raza R, Saeed A, Lecka J, Sévigny J, Iqbal J. Raza R, et al. Among authors: lecka j. Med Chem. 2012 Nov;8(6):1133-9. doi: 10.2174/1573406411208061133. Med Chem. 2012. PMID: 22741787

2

Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.

Iqbal J, Saeed A, Raza R, Matin A, Hameed A, Furtmann N, Lecka J, Sévigny J, Bajorath J. Iqbal J, et al. Among authors: lecka j. Eur J Med Chem. 2013;70:685-91. doi: 10.1016/j.ejmech.2013.10.053. Epub 2013 Oct 28. Eur J Med Chem. 2013. PMID: 24215819

3

2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases.

al-Rashida M, Batool G, Sattar A, Ejaz SA, Khan S, Lecka J, Sévigny J, Hameed A, Iqbal J. al-Rashida M, et al. Among authors: lecka j. Eur J Med Chem. 2016 Jun 10;115:484-94. doi: 10.1016/j.ejmech.2016.02.073. Epub 2016 Mar 3. Eur J Med Chem. 2016. PMID: 27054295

4

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.

Channar PA, Shah SJ, Hassan S, Nisa ZU, Lecka J, Sévigny J, Bajorath J, Saeed A, Iqbal J. Channar PA, et al. Among authors: lecka j. Chem Biol Drug Des. 2017 Mar;89(3):365-370. doi: 10.1111/cbdd.12861. Epub 2016 Oct 26. Chem Biol Drug Des. 2017. PMID: 27589035

5

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.

Ejaz SA, Saeed A, Siddique MN, Nisa ZU, Khan S, Lecka J, Sévigny J, Iqbal J. Ejaz SA, et al. Among authors: lecka j. Bioorg Chem. 2017 Feb;70:229-236. doi: 10.1016/j.bioorg.2017.01.003. Epub 2017 Jan 5. Bioorg Chem. 2017. PMID: 28110961

6

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.

Kuhrt D, Ejaz SA, Afzal S, Khan SU, Lecka J, Sévigny J, Ehlers P, Spannenberg A, Iqbal J, Langer P. Kuhrt D, et al. Among authors: lecka j. Eur J Med Chem. 2017 Sep 29;138:816-829. doi: 10.1016/j.ejmech.2017.07.017. Epub 2017 Jul 13. Eur J Med Chem. 2017. PMID: 28735213

7

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity.

Hassan S, Ejaz SA, Saeed A, Shehzad M, Ullah Khan S, Lecka J, Sévigny J, Shabir G, Iqbal J. Hassan S, et al. Among authors: lecka j. Bioorg Chem. 2018 Feb;76:237-248. doi: 10.1016/j.bioorg.2017.11.013. Epub 2017 Nov 21. Bioorg Chem. 2018. PMID: 29197225

8

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.

Ashraf A, Ejaz SA, Rahman SU, Siddiqui WA, Arshad MN, Lecka J, Sévigny J, Zayed MEM, Asiri AM, Iqbal J, Hartinger CG, Hanif M. Ashraf A, et al. Among authors: lecka j. Eur J Med Chem. 2018 Nov 5;159:282-291. doi: 10.1016/j.ejmech.2018.09.063. Epub 2018 Sep 26. Eur J Med Chem. 2018. PMID: 30296687

9

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold.

Afzal S, Zaib S, Jafari B, Langer P, Lecka J, Sévigny J, Iqbal J. Afzal S, et al. Among authors: lecka j. Med Chem. 2020;16(5):689-702. doi: 10.2174/1573406415666190614095821. Med Chem. 2020. PMID: 31203806

10

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.

al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J. al-Rashida M, et al. Among authors: lecka j. Eur J Med Chem. 2013 Aug;66:438-49. doi: 10.1016/j.ejmech.2013.06.015. Epub 2013 Jun 19. Eur J Med Chem. 2013. PMID: 23831808

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