Parker WB - Search Results

1

In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.

Sorscher EJ, Hong JS, Allan PW, Waud WR, Parker WB. Sorscher EJ, et al. Among authors: parker wb. Cancer Chemother Pharmacol. 2012 Aug;70(2):321-9. doi: 10.1007/s00280-012-1908-9. Epub 2012 Jul 4. Cancer Chemother Pharmacol. 2012. PMID: 22760227 Free PMC article.

2

Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase.

Parker WB, Allan PW, Hassan AE, Secrist JA 3rd, Sorscher EJ, Waud WR. Parker WB, et al. Cancer Gene Ther. 2003 Jan;10(1):23-9. doi: 10.1038/sj.cgt.7700520. Cancer Gene Ther. 2003. PMID: 12489025

3

A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration.

Gadi VK, Alexander SD, Waud WR, Allan PW, Parker WB, Sorscher EJ. Gadi VK, et al. Among authors: parker wb. J Pharmacol Exp Ther. 2003 Mar;304(3):1280-4. doi: 10.1124/jpet.102.044743. J Pharmacol Exp Ther. 2003. PMID: 12604707

4

Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.

Hong JS, Waud WR, Levasseur DN, Townes TM, Wen H, McPherson SA, Moore BA, Bebok Z, Allan PW, Secrist JA 3rd, Parker WB, Sorscher EJ. Hong JS, et al. Among authors: parker wb. Cancer Res. 2004 Sep 15;64(18):6610-5. doi: 10.1158/0008-5472.CAN-04-0012. Cancer Res. 2004. PMID: 15374975

5

Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy.

Bharara S, Sorscher EJ, Gillespie GY, Lindsey JR, Hong JS, Curlee KV, Allan PW, Gadi VK, Alexander SA, Secrist JA 3rd, Parker WB, Waud WR. Bharara S, et al. Among authors: parker wb. Hum Gene Ther. 2005 Mar;16(3):339-47. doi: 10.1089/hum.2005.16.339. Hum Gene Ther. 2005. PMID: 15812229

6

Long intracellular retention of 4'-thio-arabinofuranosylcytosine 5'-triphosphate as a critical factor for the anti-solid tumor activity of 4'-thio-arabinofuranosylcytosine.

Someya H, Waud WR, Parker WB. Someya H, et al. Among authors: parker wb. Cancer Chemother Pharmacol. 2006 Jun;57(6):772-80. doi: 10.1007/s00280-005-0126-0. Epub 2005 Sep 23. Cancer Chemother Pharmacol. 2006. PMID: 16180016

7

Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.

Parker WB, Allan PW, Ealick SE, Sorscher EJ, Hassan AE, Silamkoti AV, Fowler AT, Waud WR, Secrist JA 3rd. Parker WB, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):387-92. doi: 10.1081/ncn-200059807. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247956

8

Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine.

Parker WB, Shaddix SC, Gilbert KS, Shepherd RV, Waud WR. Parker WB, et al. Cancer Chemother Pharmacol. 2009 Jul;64(2):253-61. doi: 10.1007/s00280-008-0862-z. Epub 2008 Nov 11. Cancer Chemother Pharmacol. 2009. PMID: 19002461

9

Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.

Hassan AE, Abou-Elkhair RA, Riordan JM, Allan PW, Parker WB, Khare R, Waud WR, Montgomery JA, Secrist JA 3rd. Hassan AE, et al. Among authors: parker wb. Eur J Med Chem. 2012 Jan;47(1):167-74. doi: 10.1016/j.ejmech.2011.10.039. Epub 2011 Nov 4. Eur J Med Chem. 2012. PMID: 22112758 Free PMC article.

10

6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.

Hassan AEA, Abou-Elkhair RAI, Parker WB, Allan PW, Secrist JA 3rd. Hassan AEA, et al. Among authors: parker wb. Eur J Med Chem. 2016 Jan 27;108:616-622. doi: 10.1016/j.ejmech.2015.12.029. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26724729

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