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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.
Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, San Miguel JF, Garayoa M, Weilbaecher KN. Hurchla MA, et al. Among authors: weilbaecher kn. Leukemia. 2013 Feb;27(2):430-40. doi: 10.1038/leu.2012.183. Epub 2012 Jul 5. Leukemia. 2013. PMID: 22763387 Free PMC article.
Platelet and osteoclast beta3 integrins are critical for bone metastasis.
Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN. Bakewell SJ, et al. Among authors: weilbaecher kn. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14205-10. doi: 10.1073/pnas.2234372100. Epub 2003 Nov 11. Proc Natl Acad Sci U S A. 2003. PMID: 14612570 Free PMC article.
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone.
Hirbe AC, Rubin J, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Weilbaecher KN. Hirbe AC, et al. Among authors: weilbaecher kn. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14062-7. doi: 10.1073/pnas.0705203104. Epub 2007 Aug 22. Proc Natl Acad Sci U S A. 2007. PMID: 17715292 Free PMC article.
CD47 regulates bone mass and tumor metastasis to bone.
Uluçkan O, Becker SN, Deng H, Zou W, Prior JL, Piwnica-Worms D, Frazier WA, Weilbaecher KN. Uluçkan O, et al. Among authors: weilbaecher kn. Cancer Res. 2009 Apr 1;69(7):3196-204. doi: 10.1158/0008-5472.CAN-08-3358. Epub 2009 Mar 10. Cancer Res. 2009. PMID: 19276363 Free PMC article.
The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.
Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN. Rauch DA, et al. Among authors: weilbaecher kn. PLoS One. 2010 Dec 30;5(12):e15755. doi: 10.1371/journal.pone.0015755. PLoS One. 2010. PMID: 21209895 Free PMC article.
122 results