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The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.
Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Medina-Gomez G, et al. Diabetes. 2005 Jun;54(6):1706-16. doi: 10.2337/diabetes.54.6.1706. Diabetes. 2005. PMID: 15919792 Free PMC article.
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. Lelliott CJ, et al. PLoS Biol. 2006 Nov;4(11):e369. doi: 10.1371/journal.pbio.0040369. PLoS Biol. 2006. PMID: 17090215 Free PMC article.
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. López M, et al. Cell Metab. 2008 May;7(5):389-99. doi: 10.1016/j.cmet.2008.03.006. Cell Metab. 2008. PMID: 18460330 Free article.
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice.
Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M, O'Rahilly S, Gray SL, Shah AM, Vidal-Puig A. Kis A, et al. Eur J Heart Fail. 2009 Jun;11(6):533-41. doi: 10.1093/eurjhf/hfp048. Epub 2009 Apr 24. Eur J Heart Fail. 2009. PMID: 19395708 Free PMC article.
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.
Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP. Rodriguez-Cuenca S, et al. Free Radic Biol Med. 2010 Jan 1;48(1):161-72. doi: 10.1016/j.freeradbiomed.2009.10.039. Epub 2009 Oct 23. Free Radic Biol Med. 2010. PMID: 19854266
352 results