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Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.
Van Rompay KK, Trott KA, Jayashankar K, Geng Y, LaBranche CC, Johnson JA, Landucci G, Lipscomb J, Tarara RP, Canfield DR, Heneine W, Forthal DN, Montefiori D, Abel K. Van Rompay KK, et al. Among authors: geng y. Retrovirology. 2012 Jul 17;9:57. doi: 10.1186/1742-4690-9-57. Retrovirology. 2012. PMID: 22805180 Free PMC article.
Compared to subcutaneous tenofovir, oral tenofovir disoproxyl fumarate administration preferentially concentrates the drug into gut-associated lymphoid cells in simian immunodeficiency virus-infected macaques.
Van Rompay KK, Babusis D, Abbott Z, Geng Y, Jayashankar K, Johnson JA, Lipscomb J, Heneine W, Abel K, Ray AS. Van Rompay KK, et al. Among authors: geng y. Antimicrob Agents Chemother. 2012 Sep;56(9):4980-4. doi: 10.1128/AAC.01095-12. Epub 2012 Jul 9. Antimicrob Agents Chemother. 2012. PMID: 22777046 Free PMC article.
4,039 results