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[Roles of mTORC1 in acute myeloid leukemia].
Hoshii T, Hirao A. Hoshii T, et al. Among authors: hirao a. Rinsho Ketsueki. 2015 Apr;56(4):359-65. doi: 10.11406/rinketsu.56.359. Rinsho Ketsueki. 2015. PMID: 25971265 Review. Japanese.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M. Ichimura Y, et al. Among authors: hirao a. Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. Mol Cell. 2013. PMID: 24011591 Free article.
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.
Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A. Hoshii T, et al. Among authors: hirao a. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567410 Free PMC article.
mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, Soga T, Araki K, Yamamura K, Hirao A. Hoshii T, et al. Among authors: hirao a. J Clin Invest. 2012 Jun;122(6):2114-29. doi: 10.1172/JCI62279. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622041 Free PMC article.
284 results