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A whole-cell computational model predicts phenotype from genotype.
Karr JR, Sanghvi JC, Macklin DN, Gutschow MV, Jacobs JM, Bolival B Jr, Assad-Garcia N, Glass JI, Covert MW. Karr JR, et al. Cell. 2012 Jul 20;150(2):389-401. doi: 10.1016/j.cell.2012.05.044. Cell. 2012. PMID: 22817898 Free PMC article.
WholeCellViz: data visualization for whole-cell models.
Lee R, Karr JR, Covert MW. Lee R, et al. Among authors: karr jr. BMC Bioinformatics. 2013 Aug 21;14:253. doi: 10.1186/1471-2105-14-253. BMC Bioinformatics. 2013. PMID: 23964998 Free PMC article.
Accelerated discovery via a whole-cell model.
Sanghvi JC, Regot S, Carrasco S, Karr JR, Gutschow MV, Bolival B Jr, Covert MW. Sanghvi JC, et al. Among authors: karr jr. Nat Methods. 2013 Dec;10(12):1192-5. doi: 10.1038/nmeth.2724. Epub 2013 Nov 3. Nat Methods. 2013. PMID: 24185838 Free PMC article.
Building Structural Models of a Whole Mycoplasma Cell.
Maritan M, Autin L, Karr J, Covert MW, Olson AJ, Goodsell DS. Maritan M, et al. J Mol Biol. 2022 Jan 30;434(2):167351. doi: 10.1016/j.jmb.2021.167351. Epub 2021 Nov 10. J Mol Biol. 2022. PMID: 34774566 Free PMC article.
Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.
Karr JR, Williams AH, Zucker JD, Raue A, Steiert B, Timmer J, Kreutz C; DREAM8 Parameter Estimation Challenge Consortium; Wilkinson S, Allgood BA, Bot BM, Hoff BR, Kellen MR, Covert MW, Stolovitzky GA, Meyer P. Karr JR, et al. PLoS Comput Biol. 2015 May 28;11(5):e1004096. doi: 10.1371/journal.pcbi.1004096. eCollection 2015 May. PLoS Comput Biol. 2015. PMID: 26020786 Free PMC article.
64 results