Hirota T - Search Results

1

Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.

Ieiri I, Fukae M, Maeda K, Ando Y, Kimura M, Hirota T, Nakamura T, Iwasaki K, Matsuki S, Matsuguma K, Kanda E, Deguchi M, Irie S, Sugiyama Y. Ieiri I, et al. Among authors: hirota t. Int J Clin Pharmacol Ther. 2012 Oct;50(10):689-700. doi: 10.5414/CP201763. Int J Clin Pharmacol Ther. 2012. PMID: 22853867

2

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.

Hirota T, Ieiri I, Takane H, Sano H, Kawamoto K, Aono H, Yamasaki A, Takeuchi H, Masada M, Shimizu E, Higuchi S, Otsubo K. Hirota T, et al. Drug Metab Dispos. 2003 May;31(5):677-80. doi: 10.1124/dmd.31.5.677. Drug Metab Dispos. 2003. PMID: 12695358

3

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y. Nishizato Y, et al. Among authors: hirota t. Clin Pharmacol Ther. 2003 Jun;73(6):554-65. doi: 10.1016/S0009-9236(03)00060-2. Clin Pharmacol Ther. 2003. PMID: 12811365

4

Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene.

Takane H, Kobayashi D, Hirota T, Kigawa J, Terakawa N, Otsubo K, Ieiri I. Takane H, et al. Among authors: hirota t. J Pharmacol Exp Ther. 2004 Dec;311(3):1179-87. doi: 10.1124/jpet.104.069724. Epub 2004 Jul 27. J Pharmacol Exp Ther. 2004. PMID: 15280437

5

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

Hirota T, Ieiri I, Takane H, Maegawa S, Hosokawa M, Kobayashi K, Chiba K, Nanba E, Oshimura M, Sato T, Higuchi S, Otsubo K. Hirota T, et al. Hum Mol Genet. 2004 Dec 1;13(23):2959-69. doi: 10.1093/hmg/ddh313. Epub 2004 Sep 30. Hum Mol Genet. 2004. PMID: 15459178

6

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

Kobayashi D, Ieiri I, Hirota T, Takane H, Maegawa S, Kigawa J, Suzuki H, Nanba E, Oshimura M, Terakawa N, Otsubo K, Mine K, Sugiyama Y. Kobayashi D, et al. Among authors: hirota t. Drug Metab Dispos. 2005 Jan;33(1):94-101. doi: 10.1124/dmd.104.001628. Epub 2004 Oct 8. Drug Metab Dispos. 2005. PMID: 15475413

7

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy.

Ieiri I, Takane H, Hirota T, Otsubo K, Higuchi S. Ieiri I, et al. Among authors: hirota t. Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):651-74. doi: 10.1517/17425255.2.5.651. Expert Opin Drug Metab Toxicol. 2006. PMID: 17014387 Review.

8

Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms.

Hirota T, Takane H, Higuchi S, Ieiri I. Hirota T, et al. Curr Drug Metab. 2008 Jan;9(1):34-8. doi: 10.2174/138920008783331130. Curr Drug Metab. 2008. PMID: 18220569 Review.

9

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism.

Suwannakul S, Ieiri I, Kimura M, Kawabata K, Kusuhara H, Hirota T, Irie S, Sugiyama Y, Higuchi S. Suwannakul S, et al. Among authors: hirota t. J Hum Genet. 2008;53(10):899-904. doi: 10.1007/s10038-008-0324-9. Epub 2008 Jul 19. J Hum Genet. 2008. PMID: 18641915

10

Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients.

Sasaki T, Takane H, Ogawa K, Isagawa S, Hirota T, Higuchi S, Horii T, Otsubo K, Ieiri I. Sasaki T, et al. Among authors: hirota t. Antimicrob Agents Chemother. 2011 May;55(5):1867-73. doi: 10.1128/AAC.01185-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357301 Free PMC article. Clinical Trial.

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