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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. Lerner AG, et al. Among authors: nguyen v. Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007. Cell Metab. 2012. PMID: 22883233 Free PMC article.
Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).
Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG. Lee RH, et al. Among authors: nguyen v. Transplant Proc. 2014 Jul-Aug;46(6):2002-6. doi: 10.1016/j.transproceed.2014.05.068. Transplant Proc. 2014. PMID: 25131094 Free PMC article.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Bluestone JA, et al. Among authors: nguyen v. Sci Transl Med. 2015 Nov 25;7(315):315ra189. doi: 10.1126/scitranslmed.aad4134. Sci Transl Med. 2015. PMID: 26606968 Free PMC article. Clinical Trial.
Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.
Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Chandran S, et al. Among authors: nguyen v. Am J Transplant. 2017 Nov;17(11):2945-2954. doi: 10.1111/ajt.14415. Epub 2017 Aug 14. Am J Transplant. 2017. PMID: 28675676 Free PMC article. Clinical Trial.
5,226 results