De Schutter JW - Search Results

1

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.

De Schutter JW, Shaw J, Lin YS, Tsantrizos YS. De Schutter JW, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5583-91. doi: 10.1016/j.bmc.2012.07.019. Epub 2012 Jul 24. Bioorg Med Chem. 2012. PMID: 22884353

2

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.

De Schutter JW, Zaretsky S, Welbourn S, Pause A, Tsantrizos YS. De Schutter JW, et al. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5781-6. doi: 10.1016/j.bmcl.2010.07.133. Epub 2010 Aug 11. Bioorg Med Chem Lett. 2010. PMID: 20801032

3

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.

Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, Tsantrizos YS. Lin YS, et al. Among authors: de schutter jw. J Med Chem. 2012 Apr 12;55(7):3201-15. doi: 10.1021/jm201657x. Epub 2012 Mar 19. J Med Chem. 2012. PMID: 22390415

4

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: de schutter jw. BMC Struct Biol. 2012 Dec 12;12:32. doi: 10.1186/1472-6807-12-32. BMC Struct Biol. 2012. PMID: 23234314 Free PMC article.

5

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.

Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Leung CY, et al. Among authors: de schutter jw. J Med Chem. 2013 Oct 24;56(20):7939-50. doi: 10.1021/jm400946f. Epub 2013 Oct 3. J Med Chem. 2013. PMID: 23998921

6

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.

De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, Berghuis AM, Poirier J, Tsantrizos YS. De Schutter JW, et al. J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23. J Med Chem. 2014. PMID: 24911527

7

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.

Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, Lacbay CM, Zielinski M, Berghuis AM, Tsantrizos YS. Gritzalis D, et al. Among authors: de schutter jw. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1117-23. doi: 10.1016/j.bmcl.2014.12.089. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25630225

8

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM. Park J, et al. Among authors: de schutter jw. PLoS One. 2017 Oct 16;12(10):e0186447. doi: 10.1371/journal.pone.0186447. eCollection 2017. PLoS One. 2017. PMID: 29036218 Free PMC article.

9

Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni.

De Schutter JW, Morrison JP, Morrison MJ, Ciulli A, Imperiali B. De Schutter JW, et al. J Med Chem. 2017 Mar 9;60(5):2099-2118. doi: 10.1021/acs.jmedchem.6b01869. Epub 2017 Feb 22. J Med Chem. 2017. PMID: 28182413 Free PMC article.

10

Toward a computational tool predicting the stereochemical outcome of asymmetric reactions: development of the molecular mechanics-based program ACE and application to asymmetric epoxidation reactions.

Weill N, Corbeil CR, De Schutter JW, Moitessier N. Weill N, et al. Among authors: de schutter jw. J Comput Chem. 2011 Oct;32(13):2878-89. doi: 10.1002/jcc.21869. Epub 2011 Jul 6. J Comput Chem. 2011. PMID: 21735450

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