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Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells.
Tsukamoto S, Hirotsu K, Kumazoe M, Goto Y, Sugihara K, Suda T, Tsurudome Y, Suzuki T, Yamashita S, Kim Y, Huang Y, Yamada K, Tachibana H. Tsukamoto S, et al. Among authors: huang y. Biochem J. 2012 Apr 15;443(2):525-34. doi: 10.1042/BJ20111837. Biochem J. 2012. PMID: 22257159
67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis.
Kumazoe M, Sugihara K, Tsukamoto S, Huang Y, Tsurudome Y, Suzuki T, Suemasu Y, Ueda N, Yamashita S, Kim Y, Yamada K, Tachibana H. Kumazoe M, et al. Among authors: huang y. J Clin Invest. 2013 Feb;123(2):787-99. doi: 10.1172/JCI64768. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348740 Free PMC article.
Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis.
Kumazoe M, Kim Y, Bae J, Takai M, Murata M, Suemasu Y, Sugihara K, Yamashita S, Tsukamoto S, Huang Y, Nakahara K, Yamada K, Tachibana H. Kumazoe M, et al. Among authors: huang y. FEBS Lett. 2013 Sep 17;587(18):3052-7. doi: 10.1016/j.febslet.2013.07.041. Epub 2013 Aug 1. FEBS Lett. 2013. PMID: 23916810 Free article.
Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.
Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, Bae J, Yamashita S, Murata M, Yamada S, Shinoda Y, Yamaguchi W, Toyoda Y, Tachibana H. Kumazoe M, et al. Among authors: huang y. J Biol Chem. 2017 Mar 10;292(10):4077-4088. doi: 10.1074/jbc.M116.755959. Epub 2017 Feb 1. J Biol Chem. 2017. PMID: 28154178 Free PMC article.
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