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Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE. Kim JH, et al. Among authors: sikka g. J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008. Epub 2009 Aug 6. J Appl Physiol (1985). 2009. PMID: 19661445 Free PMC article.
Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness.
Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ, Sikka G, Kuo M, Halushka MK, Macgregor AM, Dunn J, Gutbrod S, Yin D, Shoukas A, Nyhan D, Flavahan NA, Belkin AM, Berkowitz DE. Santhanam L, et al. Among authors: sikka g. Circ Res. 2010 Jul 9;107(1):117-25. doi: 10.1161/CIRCRESAHA.109.215228. Epub 2010 May 20. Circ Res. 2010. PMID: 20489165
Melanopsin mediates light-dependent relaxation in blood vessels.
Sikka G, Hussmann GP, Pandey D, Cao S, Hori D, Park JT, Steppan J, Kim JH, Barodka V, Myers AC, Santhanam L, Nyhan D, Halushka MK, Koehler RC, Snyder SH, Shimoda LA, Berkowitz DE. Sikka G, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17977-82. doi: 10.1073/pnas.1420258111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404319 Free PMC article.
Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition.
Barreto Ortiz S, Hori D, Nomura Y, Yun X, Jiang H, Yong H, Chen J, Paek S, Pandey D, Sikka G, Bhatta A, Gillard A, Steppan J, Kim JH, Adachi H, Barodka VM, Romer L, An SS, Shimoda LA, Santhanam L, Berkowitz DE. Barreto Ortiz S, et al. Among authors: sikka g. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L93-L106. doi: 10.1152/ajplung.00091.2017. Epub 2017 Sep 7. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 28882814 Free PMC article.
41 results