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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Gwilt KB, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Jena KK, et al. Among authors: spinelli l. Cell. 2024 Oct 30:S0092-8674(24)01158-9. doi: 10.1016/j.cell.2024.10.010. Online ahead of print. Cell. 2024. PMID: 39500322
Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis.
Rapacciuolo P, Finamore C, Giorgio CD, Fiorillo B, Massa C, Urbani G, Marchianò S, Bordoni M, Cassiano C, Morretta E, Spinelli L, Lupia A, Moraca F, Biagioli M, Sepe V, Monti MC, Catalanotti B, Fiorucci S, Zampella A. Rapacciuolo P, et al. Among authors: spinelli l. J Med Chem. 2024 Oct 24;67(20):18334-18355. doi: 10.1021/acs.jmedchem.4c01651. Epub 2024 Oct 9. J Med Chem. 2024. PMID: 39382988
451 results