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Predicting protein targets for drug-like compounds using transcriptomics.
Pabon NA, Xia Y, Estabrooks SK, Ye Z, Herbrand AK, Süß E, Biondi RM, Assimon VA, Gestwicki JE, Brodsky JL, Camacho CJ, Bar-Joseph Z. Pabon NA, et al. Among authors: gestwicki je. PLoS Comput Biol. 2018 Dec 7;14(12):e1006651. doi: 10.1371/journal.pcbi.1006651. eCollection 2018 Dec. PLoS Comput Biol. 2018. PMID: 30532261 Free PMC article.
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Sabnis AJ, et al. Among authors: gestwicki je. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22. Proc Natl Acad Sci U S A. 2016. PMID: 27450084 Free PMC article.
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.
Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. Shao H, et al. Among authors: gestwicki je. Cell Chem Biol. 2022 Aug 18;29(8):1303-1316.e3. doi: 10.1016/j.chembiol.2022.06.006. Epub 2022 Jul 12. Cell Chem Biol. 2022. PMID: 35830852 Free PMC article.
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: gestwicki je. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: gestwicki je. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
Jinwal UK, Miyata Y, Koren J 3rd, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Jinwal UK, et al. Among authors: gestwicki je. J Neurosci. 2009 Sep 30;29(39):12079-88. doi: 10.1523/JNEUROSCI.3345-09.2009. J Neurosci. 2009. PMID: 19793966 Free PMC article.
Pharmacological targeting of the Hsp70 chaperone.
Patury S, Miyata Y, Gestwicki JE. Patury S, et al. Among authors: gestwicki je. Curr Top Med Chem. 2009;9(15):1337-51. doi: 10.2174/156802609789895674. Curr Top Med Chem. 2009. PMID: 19860737 Free PMC article. Review.
243 results