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β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME. Cai J, et al. Among authors: golde t. EMBO Mol Med. 2012 Sep;4(9):980-91. doi: 10.1002/emmm.201101084. Epub 2012 Aug 20. EMBO Mol Med. 2012. PMID: 22903875 Free PMC article.
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.
Steroids as γ-secretase modulators.
Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Jung JI, et al. Among authors: golde te. FASEB J. 2013 Sep;27(9):3775-85. doi: 10.1096/fj.12-225649. Epub 2013 May 28. FASEB J. 2013. PMID: 23716494 Free PMC article.
γ-Secretase inhibitors and modulators.
Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. Golde TE, et al. Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Biochim Biophys Acta. 2013. PMID: 23791707 Free PMC article. Review.
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.
Marino M, Zhou L, Rincon MY, Callaerts-Vegh Z, Verhaert J, Wahis J, Creemers E, Yshii L, Wierda K, Saito T, Marneffe C, Voytyuk I, Wouters Y, Dewilde M, Duqué SI, Vincke C, Levites Y, Golde TE, Saido TC, Muyldermans S, Liston A, De Strooper B, Holt MG. Marino M, et al. Among authors: golde te. EMBO Mol Med. 2022 Apr 7;14(4):e09824. doi: 10.15252/emmm.201809824. Epub 2022 Mar 30. EMBO Mol Med. 2022. PMID: 35352880 Free PMC article.
360 results