Wear MA - Search Results

1

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. Morgan HP, et al. Among authors: wear ma. Biochem J. 2012 Nov 15;448(1):67-72. doi: 10.1042/BJ20121014. Biochem J. 2012. PMID: 22906073 Free PMC article.

2

Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.

Yang Y, Moir E, Kontopidis G, Taylor P, Wear MA, Malone K, Dunsmore CJ, Page AP, Turner NJ, Walkinshaw MD. Yang Y, et al. Among authors: wear ma. Biochem Biophys Res Commun. 2007 Nov 30;363(4):1013-9. doi: 10.1016/j.bbrc.2007.09.079. Epub 2007 Oct 1. Biochem Biophys Res Commun. 2007. PMID: 17927958

3

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.

Morgan HP, O'Reilly FJ, Wear MA, O'Neill JR, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD. Morgan HP, et al. Among authors: wear ma. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5881-6. doi: 10.1073/pnas.1217157110. Epub 2013 Mar 25. Proc Natl Acad Sci U S A. 2013. PMID: 23530218 Free PMC article.

4

Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states.

Blackburn EA, Fuad FA, Morgan HP, Nowicki MW, Wear MA, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD. Blackburn EA, et al. Among authors: wear ma. Biochem Biophys Res Commun. 2014 Jul 25;450(2):936-41. doi: 10.1016/j.bbrc.2014.06.113. Epub 2014 Jun 28. Biochem Biophys Res Commun. 2014. PMID: 24984149

5

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.

Yuan M, McNae IW, Chen Y, Blackburn EA, Wear MA, Michels PAM, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD. Yuan M, et al. Among authors: wear ma. Biochem J. 2018 May 31;475(10):1821-1837. doi: 10.1042/BCJ20180171. Biochem J. 2018. PMID: 29748232 Free PMC article.

6

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation.

Mitchell AR, Yuan M, Morgan HP, McNae IW, Blackburn EA, Le Bihan T, Homem RA, Yu M, Loake GJ, Michels PA, Wear MA, Walkinshaw MD. Mitchell AR, et al. Among authors: wear ma. Biochem J. 2018 Oct 31;475(20):3275-3291. doi: 10.1042/BCJ20180556. Biochem J. 2018. PMID: 30254098 Free PMC article.

7

Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders.

Georgiou C, McNae I, Wear M, Ioannidis H, Michel J, Walkinshaw M. Georgiou C, et al. J Mol Biol. 2017 Aug 4;429(16):2556-2570. doi: 10.1016/j.jmb.2017.06.016. Epub 2017 Jun 30. J Mol Biol. 2017. PMID: 28673552

8

Thermodynamics of the cyclophilin-A/cyclosporin-A interaction: a direct comparison of parameters determined by surface plasmon resonance using Biacore T100 and isothermal titration calorimetry.

Wear MA, Walkinshaw MD. Wear MA, et al. Anal Biochem. 2006 Dec 15;359(2):285-7. doi: 10.1016/j.ab.2006.08.038. Epub 2006 Sep 22. Anal Biochem. 2006. PMID: 17069746 No abstract available.

9

Determination of the rate constants for the FK506 binding protein/rapamycin interaction using surface plasmon resonance: an alternative sensor surface for Ni2+-nitrilotriacetic acid immobilization of His-tagged proteins.

Wear MA, Walkinshaw MD. Wear MA, et al. Anal Biochem. 2007 Dec 15;371(2):250-2. doi: 10.1016/j.ab.2007.06.034. Epub 2007 Jun 27. Anal Biochem. 2007. PMID: 17655818 No abstract available.

10

Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium.

Morgan HP, Wear MA, McNae I, Gallagher MP, Walkinshaw MD. Morgan HP, et al. Among authors: wear ma. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1240-5. doi: 10.1107/S1744309109033788. Epub 2009 Nov 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 20054119 Free PMC article.

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