Qi W - Search Results

1

Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies.

Mahadevan D, Chiorean EG, Harris WB, Von Hoff DD, Stejskal-Barnett A, Qi W, Anthony SP, Younger AE, Rensvold DM, Cordova F, Shelton CF, Becker MD, Garlich JR, Durden DL, Ramanathan RK. Mahadevan D, et al. Among authors: qi w. Eur J Cancer. 2012 Dec;48(18):3319-27. doi: 10.1016/j.ejca.2012.06.027. Epub 2012 Aug 23. Eur J Cancer. 2012. PMID: 22921184 Free PMC article. Clinical Trial.

2

AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas.

Qi W, Liu X, Cooke LS, Persky DO, Miller TP, Squires M, Mahadevan D. Qi W, et al. Int J Cancer. 2012 Jun 15;130(12):2997-3005. doi: 10.1002/ijc.26324. Epub 2011 Nov 19. Int J Cancer. 2012. PMID: 21796626

3

MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer.

Qi W, Cooke LS, Stejskal A, Riley C, Croce KD, Saldanha JW, Bearss D, Mahadevan D. Qi W, et al. BMC Cancer. 2009 May 11;9:142. doi: 10.1186/1471-2407-9-142. BMC Cancer. 2009. PMID: 19432987 Free PMC article.

4

Disruption of Aneuploidy and Senescence Induced by Aurora Inhibition Promotes Intrinsic Apoptosis in Double Hit or Double Expressor Diffuse Large B-cell Lymphomas.

Islam S, Qi W, Morales C, Cooke L, Spier C, Weterings E, Mahadevan D. Islam S, et al. Among authors: qi w. Mol Cancer Ther. 2017 Oct;16(10):2083-2093. doi: 10.1158/1535-7163.MCT-17-0089. Epub 2017 Jun 14. Mol Cancer Ther. 2017. PMID: 28615297 Free PMC article.

5

Design and activity of a murine and humanized anti-CEACAM6 single-chain variable fragment in the treatment of pancreatic cancer.

Riley CJ, Engelhardt KP, Saldanha JW, Qi W, Cooke LS, Zhu Y, Narayan ST, Shakalya K, Croce KD, Georgiev IG, Nagle RB, Garewal H, Von Hoff DD, Mahadevan D. Riley CJ, et al. Among authors: qi w. Cancer Res. 2009 Mar 1;69(5):1933-40. doi: 10.1158/0008-5472.CAN-08-2707. Epub 2009 Feb 24. Cancer Res. 2009. PMID: 19244123 Free PMC article.

6

Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma.

Qi W, Cooke LS, Liu X, Rimsza L, Roe DJ, Manziolli A, Persky DO, Miller TP, Mahadevan D. Qi W, et al. Biochem Pharmacol. 2011 Apr 1;81(7):881-90. doi: 10.1016/j.bcp.2011.01.017. Epub 2011 Feb 1. Biochem Pharmacol. 2011. PMID: 21291867 Free PMC article.

7

Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment.

Qi W, Spier C, Liu X, Agarwal A, Cooke LS, Persky DO, Chen D, Miller TP, Mahadevan D. Qi W, et al. Leuk Res. 2013 Apr;37(4):434-9. doi: 10.1016/j.leukres.2012.10.017. Epub 2012 Nov 12. Leuk Res. 2013. PMID: 23153524 Free PMC article.

8

Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma.

Mahadevan D, Stejskal A, Cooke LS, Manziello A, Morales C, Persky DO, Fisher RI, Miller TP, Qi W. Mahadevan D, et al. Among authors: qi w. Clin Cancer Res. 2012 Apr 15;18(8):2210-9. doi: 10.1158/1078-0432.CCR-11-2413. Epub 2012 Feb 28. Clin Cancer Res. 2012. PMID: 22374334 Free PMC article.

9

An analog of withaferin A activates the MAPK and glutathione "stress" pathways and inhibits pancreatic cancer cell proliferation.

Liu X, Qi W, Cooke LS, Kithsiri Wijeratne EM, Xu YM, Marron MT, Leslie Gunatilaka AA, Mahadevan D. Liu X, et al. Among authors: qi w. Cancer Invest. 2011 Dec;29(10):668-75. doi: 10.3109/07357907.2011.626478. Cancer Invest. 2011. PMID: 22085270

10

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells.

Qi W, Shakalya K, Stejskal A, Goldman A, Beeck S, Cooke L, Mahadevan D. Qi W, et al. Oncogene. 2008 Jul 10;27(30):4210-20. doi: 10.1038/onc.2008.54. Epub 2008 Mar 17. Oncogene. 2008. PMID: 18345031

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