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CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].
Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE. Wang MZ, et al. Among authors: hall je, hall m. Drug Metab Dispos. 2006 Dec;34(12):1985-94. doi: 10.1124/dmd.106.010587. Epub 2006 Sep 22. Drug Metab Dispos. 2006. PMID: 16997912 Free PMC article.
The distribution of multiple doses of pentamidine in rats.
Berger BJ, Hall JE, Tidwell RR. Berger BJ, et al. Among authors: hall je. Pharmacol Toxicol. 1990 Mar;66(3):234-6. doi: 10.1111/j.1600-0773.1990.tb00740.x. Pharmacol Toxicol. 1990. PMID: 2333279 No abstract available.
Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.
Thuita JK, Wolf KK, Murilla GA, Liu Q, Mutuku JN, Chen Y, Bridges AS, Mdachi RE, Ismail MA, Ching S, Boykin DW, Hall JE, Tidwell RR, Paine MF, Brun R, Wang MZ. Thuita JK, et al. Among authors: hall je. PLoS Negl Trop Dis. 2013 Jun 6;7(6):e2230. doi: 10.1371/journal.pntd.0002230. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23755309 Free PMC article.
1,115 results