Varadarajan S - Search Results

1

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM. Varadarajan S, et al. Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7. Cell Death Differ. 2012. PMID: 22955944 Free PMC article.

2

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.

Son JK, Varadarajan S, Bratton SB. Son JK, et al. Among authors: varadarajan s. Cell Death Differ. 2010 Aug;17(8):1288-301. doi: 10.1038/cdd.2010.9. Epub 2010 Feb 19. Cell Death Differ. 2010. PMID: 20168333 Free PMC article.

3

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM. Varadarajan S, et al. PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15. PLoS One. 2013. PMID: 23457590 Free PMC article.

4

Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM. Varadarajan S, et al. Neoplasia. 2013 May;15(5):568-78. doi: 10.1593/neo.13230. Neoplasia. 2013. PMID: 23633928 Free PMC article.

5

Evaluation and critical assessment of putative MCL-1 inhibitors.

Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM. Varadarajan S, et al. Cell Death Differ. 2013 Nov;20(11):1475-84. doi: 10.1038/cdd.2013.79. Epub 2013 Jul 5. Cell Death Differ. 2013. PMID: 23832116 Free PMC article.

6

The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration.

Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM. Varadarajan S, et al. Cell Death Differ. 2015 Aug;22(8):1388-96. doi: 10.1038/cdd.2015.1. Epub 2015 Feb 6. Cell Death Differ. 2015. PMID: 25656655 Free PMC article.

7

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.

Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG, Cohen GM. Varadarajan S, et al. Oncotarget. 2015 May 20;6(14):12668-81. doi: 10.18632/oncotarget.3706. Oncotarget. 2015. PMID: 26059440 Free PMC article.

8

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.

Butterworth M, Pettitt A, Varadarajan S, Cohen GM. Butterworth M, et al. Among authors: varadarajan s. Br J Cancer. 2016 Mar 15;114(6):638-41. doi: 10.1038/bjc.2016.49. Epub 2016 Mar 8. Br J Cancer. 2016. PMID: 26954718 Free PMC article.

9

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S. Lucas CM, et al. Among authors: varadarajan s. Leukemia. 2016 Jun;30(6):1273-81. doi: 10.1038/leu.2016.42. Epub 2016 Feb 29. Leukemia. 2016. PMID: 26987906 Free PMC article.

10

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S. Milani M, et al. Among authors: varadarajan s. Cell Death Dis. 2017 Jan 12;8(1):e2552. doi: 10.1038/cddis.2016.485. Cell Death Dis. 2017. PMID: 28079887 Free PMC article.

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