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CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Sala M, Braida D, Pucci L, Manfredi I, Marks MJ, Wageman CR, Grady SR, Loi B, Fucile S, Fasoli F, Zoli M, Tasso B, Sparatore F, Clementi F, Gotti C. Sala M, et al. Among authors: fasoli f. Br J Pharmacol. 2013 Feb;168(4):835-49. doi: 10.1111/j.1476-5381.2012.02204.x. Br J Pharmacol. 2013. PMID: 22957729 Free PMC article.
The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors.
Ponzoni L, Braida D, Pucci L, Andrea D, Fasoli F, Manfredi I, Papke RL, Stokes C, Cannazza G, Clementi F, Gotti C, Sala M. Ponzoni L, et al. Among authors: fasoli f. Psychopharmacology (Berl). 2014 Dec;231(24):4681-93. doi: 10.1007/s00213-014-3619-x. Epub 2014 May 27. Psychopharmacology (Berl). 2014. PMID: 24862365
Structure of neuronal nicotinic receptors.
Fasoli F, Gotti C. Fasoli F, et al. Curr Top Behav Neurosci. 2015;23:1-17. doi: 10.1007/978-3-319-13665-3_1. Curr Top Behav Neurosci. 2015. PMID: 25655885 Review.
64 results