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Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22.
Raifer H, Mahiny AJ, Bollig N, Petermann F, Hellhund A, Kellner K, Guralnik A, Reinhard K, Bothur E, Huber M, Bauer S, Löhning M, Kiss EA, Ganal SC, Diefenbach A, Korn T, Lohoff M. Raifer H, et al. Among authors: bothur e. Eur J Immunol. 2012 Dec;42(12):3189-201. doi: 10.1002/eji.201142155. Epub 2012 Oct 17. Eur J Immunol. 2012. PMID: 22961652 Free article.
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.
Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Bollig N, et al. Among authors: bothur e. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2. Proc Natl Acad Sci U S A. 2012. PMID: 22552227 Free PMC article.
Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.
Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M. Bothur E, et al. Nat Commun. 2015 Oct 13;6:8576. doi: 10.1038/ncomms9576. Nat Commun. 2015. PMID: 26815406 Free PMC article.
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E, Bopp T. Staudt V, et al. Among authors: bothur e. Immunity. 2010 Aug 27;33(2):192-202. doi: 10.1016/j.immuni.2010.07.014. Epub 2010 Jul 30. Immunity. 2010. PMID: 20674401 Free article.
Reliability and suitability of physiological exercise response and recovery markers.
Reichel T, Boßlau TK, Palmowski J, Eder K, Ringseis R, Mooren FC, Walscheid R, Bothur E, Samel S, Frech T, Philippe M, Krüger K. Reichel T, et al. Among authors: bothur e. Sci Rep. 2020 Jul 17;10(1):11924. doi: 10.1038/s41598-020-69280-9. Sci Rep. 2020. PMID: 32681124 Free PMC article. Clinical Trial.