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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Génin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, André F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L. Ghiringhelli F, et al. Among authors: tschopp j. Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20. Nat Med. 2009. PMID: 19767732
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC. McNeela EA, et al. Among authors: tschopp j. PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191. PLoS Pathog. 2010. PMID: 21085613 Free PMC article.
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.
Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA. Vilaysane A, et al. Among authors: tschopp j. J Am Soc Nephrol. 2010 Oct;21(10):1732-44. doi: 10.1681/ASN.2010020143. Epub 2010 Aug 5. J Am Soc Nephrol. 2010. PMID: 20688930 Free PMC article.
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.
Dorhoi A, Nouailles G, Jörg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Müller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH. Dorhoi A, et al. Among authors: tschopp j. Eur J Immunol. 2012 Feb;42(2):374-84. doi: 10.1002/eji.201141548. Epub 2011 Dec 20. Eur J Immunol. 2012. PMID: 22101787 Free article.
623 results