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A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record.
Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA, Cross SJ, Haidar C, Baker DK, Howard SC, Evans WE, Broeckel U, Relling MV. Hicks JK, et al. Among authors: yang w. Clin Pharmacol Ther. 2012 Nov;92(5):563-6. doi: 10.1038/clpt.2012.140. Epub 2012 Sep 19. Clin Pharmacol Ther. 2012. PMID: 22990750 Free PMC article. No abstract available.
Concordance of DMET plus genotyping results with those of orthogonal genotyping methods.
Fernandez CA, Smith C, Yang W, Lorier R, Crews KR, Kornegay N, Hicks JK, Stewart CF, Kawedia JD, Ramsey LB, Liu C, Evans WE, Relling MV, Broeckel U. Fernandez CA, et al. Among authors: yang w. Clin Pharmacol Ther. 2012 Sep;92(3):360-5. doi: 10.1038/clpt.2012.95. Epub 2012 Aug 8. Clin Pharmacol Ther. 2012. PMID: 22871999 Free PMC article.
Comparison of genome sequencing and clinical genotyping for pharmacogenes.
Yang W, Wu G, Broeckel U, Smith CA, Turner V, Haidar CE, Wang S, Carter R, Karol SE, Neale G, Crews KR, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV. Yang W, et al. Among authors: yang jj. Clin Pharmacol Ther. 2016 Oct;100(4):380-8. doi: 10.1002/cpt.411. Epub 2016 Aug 18. Clin Pharmacol Ther. 2016. PMID: 27311679 Free PMC article.
Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.
Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV. Liu C, et al. Among authors: yang jj, yang w. Clin Pharmacol Ther. 2017 Mar;101(3):373-381. doi: 10.1002/cpt.463. Epub 2016 Nov 18. Clin Pharmacol Ther. 2017. PMID: 27564568 Free PMC article.
Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.
Jiang C, Yang W, Moriyama T, Liu C, Smith C, Yang W, Qian M, Li Z, Tulstrup M, Schmiegelow K, Crews KR, Zhang H, Pui CH, Evans W, Relling M, Bhatia S, Yang JJ. Jiang C, et al. Among authors: yang jj, yang w. Clin Pharmacol Ther. 2021 Jun;109(6):1538-1545. doi: 10.1002/cpt.2095. Epub 2020 Nov 24. Clin Pharmacol Ther. 2021. PMID: 33124053 Free PMC article.
Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.
Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling MV, Evans WE. Stocco G, et al. Among authors: yang w. Clin Pharmacol Ther. 2009 Feb;85(2):164-72. doi: 10.1038/clpt.2008.154. Epub 2008 Aug 6. Clin Pharmacol Ther. 2009. PMID: 18685564 Free PMC article.
Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.
Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV. Liu Y, et al. Among authors: yang jj, yang w. Clin Pharmacol Ther. 2017 Jul;102(1):131-140. doi: 10.1002/cpt.629. Epub 2017 Apr 4. Clin Pharmacol Ther. 2017. PMID: 28090653 Free PMC article.
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