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Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: yutsudo t. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Discovery of novel non-peptide thrombopoietin mimetic compounds that induce megakaryocytopoiesis.
Yamane N, Takahashi K, Tanaka Y, Kato K, Takayama M, Ohyabu N, Shiota T, Takenaka H, Yoshida Y, Hara S, Murashi T, Nakamura E, Nishitani Y, Ishizaki J, Yamane S, Nagata K, Koizumi K, Yutsudo T, Suzuki R, Itoh T, Takemoto H. Yamane N, et al. Among authors: yutsudo t. Biosci Rep. 2008 Oct;28(5):275-85. doi: 10.1042/BSR20080086. Biosci Rep. 2008. PMID: 18620546
40 results