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Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.
Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ. Lanaspa MA, et al. J Biol Chem. 2012 Nov 23;287(48):40732-44. doi: 10.1074/jbc.M112.399899. Epub 2012 Oct 3. J Biol Chem. 2012. PMID: 23035112 Free PMC article.
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.
Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ. Lanaspa MA, et al. PLoS One. 2012;7(10):e47948. doi: 10.1371/journal.pone.0047948. Epub 2012 Oct 24. PLoS One. 2012. PMID: 23112875 Free PMC article.
Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.
Rodriguez-Iturbe B, Johnson RJ, Lanaspa MA, Nakagawa T, Garcia-Arroyo FE, Sánchez-Lozada LG. Rodriguez-Iturbe B, et al. Am J Physiol Regul Integr Comp Physiol. 2022 May 1;322(5):R347-R359. doi: 10.1152/ajpregu.00238.2021. Epub 2022 Mar 10. Am J Physiol Regul Integr Comp Physiol. 2022. PMID: 35271385 Free PMC article. Review.
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Ishimoto T, et al. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5. doi: 10.1073/pnas.1119908109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371574 Free PMC article.
Hyperosmolarity drives hypertension and CKD--water and salt revisited.
Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sanchez-Lozada LG. Johnson RJ, et al. Nat Rev Nephrol. 2014 Jul;10(7):415-20. doi: 10.1038/nrneph.2014.76. Epub 2014 May 6. Nat Rev Nephrol. 2014. PMID: 24802066 Review.
Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.
Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Lanaspa MA, et al. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. doi: 10.1681/ASN.2013080901. Epub 2014 May 29. J Am Soc Nephrol. 2014. PMID: 24876114 Free PMC article.
Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.
Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Kuwabara M, et al. Hypertension. 2018 Jan;71(1):78-86. doi: 10.1161/HYPERTENSIONAHA.117.10370. Epub 2017 Dec 4. Hypertension. 2018. PMID: 29203632 Free PMC article.
High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. Lanaspa MA, et al. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. doi: 10.1073/pnas.1713837115. Epub 2018 Mar 5. Proc Natl Acad Sci U S A. 2018. PMID: 29507217 Free PMC article.
Experimental heat stress nephropathy and liver injury are improved by allopurinol.
Roncal-Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, Dawson JB, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Gárcía-Trabanino R, Romero EJ, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Roncal-Jimenez CA, et al. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F726-F733. doi: 10.1152/ajprenal.00543.2017. Epub 2018 Apr 18. Am J Physiol Renal Physiol. 2018. PMID: 29667911 Free PMC article.
297 results