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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system.
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA. Kirkby NS, et al. Among authors: leadbeater pd. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045674 Free PMC article.
Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study.
Sambu N, Dent H, Englyst N, Warner TD, Leadbeater P, Roderick P, Gray H, Simpson I, Corbett S, Calver A, Morgan J, Curzen N. Sambu N, et al. Heart. 2011 Oct;97(20):1661-7. doi: 10.1136/heartjnl-2011-300192. Epub 2011 Jul 27. Heart. 2011. PMID: 21795297 Clinical Trial.