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A potent and selective inhibitor targeting human and murine 12/15-LOX.
Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. Armstrong MM, et al. Among authors: jung je. Bioorg Med Chem. 2016 Mar 15;24(6):1183-90. doi: 10.1016/j.bmc.2016.01.042. Epub 2016 Jan 21. Bioorg Med Chem. 2016. PMID: 26899595 Free PMC article.
Akt and mTOR mediate programmed necrosis in neurons.
Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Liu Q, et al. Among authors: jung je. Cell Death Dis. 2014 Feb 27;5(2):e1084. doi: 10.1038/cddis.2014.69. Cell Death Dis. 2014. PMID: 24577082 Free PMC article.
387 results