O'Neill G - Search Results

1

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis.

Strack AM, Carballo-Jane E, Wang SP, Xue J, Ping X, McNamara LA, Thankappan A, Price O, Wolff M, Wu TJ, Kawka D, Mariano M, Burton C, Chang CH, Chen J, Menke J, Luell S, Zycband EI, Tong X, Raubertas R, Sparrow CP, Hubbard B, Woods J, O'Neill G, Waters MG, Sitlani A. Strack AM, et al. J Lipid Res. 2013 Jan;54(1):177-88. doi: 10.1194/jlr.M031344. Epub 2012 Oct 28. J Lipid Res. 2013. PMID: 23103473 Free PMC article.

2

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.

Cheng K, Wu TJ, Wu KK, Sturino C, Metters K, Gottesdiener K, Wright SD, Wang Z, O'Neill G, Lai E, Waters MG. Cheng K, et al. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. doi: 10.1073/pnas.0601574103. Epub 2006 Apr 14. Proc Natl Acad Sci U S A. 2006. PMID: 16617107 Free PMC article.

3

Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1.

Lai E, De Lepeleire I, Crumley TM, Liu F, Wenning LA, Michiels N, Vets E, O'Neill G, Wagner JA, Gottesdiener K. Lai E, et al. Clin Pharmacol Ther. 2007 Jun;81(6):849-57. doi: 10.1038/sj.clpt.6100180. Epub 2007 Mar 28. Clin Pharmacol Ther. 2007. PMID: 17392721 Clinical Trial.

4

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

Leblanc Y, Roy P, Dufresne C, Lachance N, Wang Z, O'Neill G, Greig G, Denis D, Mathieu MC, Slipetz D, Sawyer N, Tsou N. Leblanc Y, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8. doi: 10.1016/j.bmcl.2009.03.010. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19307115

5

Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist.

Lai E, Wenning LA, Crumley TM, De Lepeleire I, Liu F, de Hoon JN, Van Hecken A, Depré M, Hilliard D, Greenberg H, O'Neill G, Metters K, Gottesdiener KG, Wagner JA. Lai E, et al. Clin Pharmacol Ther. 2008 Jun;83(6):840-7. doi: 10.1038/sj.clpt.6100345. Epub 2007 Sep 19. Clin Pharmacol Ther. 2008. PMID: 17882161 Clinical Trial.

6

Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.

Li L, Beaulieu C, Carriere MC, Denis D, Greig G, Guay D, O'Neill G, Zamboni R, Wang Z. Li L, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7462-5. doi: 10.1016/j.bmcl.2010.10.018. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21036609

7

Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents.

Nagabukuro H, Villa KL, Wickham LA, Kulick AA, Gichuru L, Donnelly MJ, Voronin GO, Pereira T, Tong X, Nichols A, Alves SE, O'Neill GP, Johnson CV, Hickey EJ. Nagabukuro H, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):220-7. doi: 10.1124/jpet.111.179747. Epub 2011 Apr 1. J Pharmacol Exp Ther. 2011. PMID: 21459965 Free article.

8

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

Beaulieu C, Guay D, Wang Z, Leblanc Y, Roy P, Dufresne C, Zamboni R, Berthelette C, Day S, Tsou N, Denis D, Greig G, Mathieu MC, O'Neill G. Beaulieu C, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2696-700. doi: 10.1016/j.bmcl.2008.03.015. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18359630

9

Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.

Gervais FG, Sawyer N, Stocco R, Hamel M, Krawczyk C, Sillaots S, Denis D, Wong E, Wang Z, Gallant M, Abraham WM, Slipetz D, Crackower MA, O'Neill GP. Gervais FG, et al. Mol Pharmacol. 2011 Jan;79(1):69-76. doi: 10.1124/mol.110.068585. Epub 2010 Oct 13. Mol Pharmacol. 2011. PMID: 20943773

10

Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa.

Nantel F, Fong C, Lamontagne S, Wright DH, Giaid A, Desrosiers M, Metters KM, O'Neill GP, Gervais FG. Nantel F, et al. Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):87-101. doi: 10.1016/j.prostaglandins.2003.12.002. Prostaglandins Other Lipid Mediat. 2004. PMID: 15165034

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