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Harnessing DNA-induced immune responses for improving cancer vaccines.
Herrada AA, Rojas-Colonelli N, González-Figueroa P, Roco J, Oyarce C, Ligtenberg MA, Lladser A. Herrada AA, et al. Among authors: roco j. Hum Vaccin Immunother. 2012 Nov 1;8(11):1682-93. doi: 10.4161/hv.22345. Epub 2012 Oct 30. Hum Vaccin Immunother. 2012. PMID: 23111166 Free PMC article. Review.
A short hairpin RNA-based adjuvant targeting NF-κB repressor IκBα promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination.
Gálvez-Cancino F, Roco J, Rojas-Colonelli N, Flores C, Murgas P, Cruz-Gómez S, Oyarce C, Varas-Godoy M, Sauma D, Lladser A. Gálvez-Cancino F, et al. Among authors: roco j. Vaccine. 2017 Jul 24;35(33):4148-4154. doi: 10.1016/j.vaccine.2017.06.041. Epub 2017 Jun 27. Vaccine. 2017. PMID: 28666759
Regulatory roles of IL-10-producing human follicular T cells.
Cañete PF, Sweet RA, Gonzalez-Figueroa P, Papa I, Ohkura N, Bolton H, Roco JA, Cuenca M, Bassett KJ, Sayin I, Barry E, Lopez A, Canaday DH, Meyer-Hermann M, Doglioni C, Fazekas de St Groth B, Sakaguchi S, Cook MC, Vinuesa CG. Cañete PF, et al. Among authors: roco ja. J Exp Med. 2019 Aug 5;216(8):1843-1856. doi: 10.1084/jem.20190493. Epub 2019 Jun 17. J Exp Med. 2019. PMID: 31209070 Free PMC article.
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, Ellyard J, Shen Q, Robert PA, Cappello J, Vohra H, Zhang Y, Nowosad CR, Schiepers A, Corcoran LM, Toellner KM, Polo JM, Meyer-Hermann M, Victora GD, Vinuesa CG. Roco JA, et al. Immunity. 2019 Aug 20;51(2):337-350.e7. doi: 10.1016/j.immuni.2019.07.001. Epub 2019 Jul 30. Immunity. 2019. PMID: 31375460 Free PMC article.
Follicular regulatory T cells produce neuritin to regulate B cells.
Gonzalez-Figueroa P, Roco JA, Papa I, Núñez Villacís L, Stanley M, Linterman MA, Dent A, Canete PF, Vinuesa CG. Gonzalez-Figueroa P, et al. Cell. 2021 Apr 1;184(7):1775-1789.e19. doi: 10.1016/j.cell.2021.02.027. Epub 2021 Mar 11. Cell. 2021. PMID: 33711260 Free article.
A TNIP1-driven systemic autoimmune disorder with elevated IgG4.
Medhavy A, Athanasopoulos V, Bassett K, He Y, Stanley M, Enosi Tuipulotu D, Cappello J, Brown GJ, Gonzalez-Figueroa P, Turnbull C, Shanmuganandam S, Tummala P, Hart G, Lea-Henry T, Wang H, Nambadan S, Shen Q, Roco JA, Burgio G, Wu P, Cho E, Andrews TD, Field MA, Wu X, Ding H, Guo Q, Shen N, Man SM, Jiang SH, Cook MC, Vinuesa CG. Medhavy A, et al. Among authors: roco ja. Nat Immunol. 2024 Sep;25(9):1678-1691. doi: 10.1038/s41590-024-01902-0. Epub 2024 Jul 26. Nat Immunol. 2024. PMID: 39060650 Free PMC article.
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.
Jiang SH, Athanasopoulos V, Ellyard JI, Chuah A, Cappello J, Cook A, Prabhu SB, Cardenas J, Gu J, Stanley M, Roco JA, Papa I, Yabas M, Walters GD, Burgio G, McKeon K, Byers JM, Burrin C, Enders A, Miosge LA, Canete PF, Jelusic M, Tasic V, Lungu AC, Alexander SI, Kitching AR, Fulcher DA, Shen N, Arsov T, Gatenby PA, Babon JJ, Mallon DF, de Lucas Collantes C, Stone EA, Wu P, Field MA, Andrews TD, Cho E, Pascual V, Cook MC, Vinuesa CG. Jiang SH, et al. Among authors: roco ja. Nat Commun. 2019 May 17;10(1):2201. doi: 10.1038/s41467-019-10242-9. Nat Commun. 2019. PMID: 31101814 Free PMC article.
TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: roco ja. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response.
Serrán MG, Vernengo FF, Almada L, Beccaria CG, Gazzoni Y, Canete PF, Roco JA, Boari JT, Ramello MC, Wehrens E, Cai Y, Zuniga EI, Montes CL, Cockburn IA, Rodriguez EVA, Vinuesa CG, Gruppi A. Serrán MG, et al. Among authors: roco ja. Front Immunol. 2022 May 16;13:828734. doi: 10.3389/fimmu.2022.828734. eCollection 2022. Front Immunol. 2022. PMID: 35651611 Free PMC article.
37 results