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The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Lewis JP, Horenstein RB, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Tanner K, Chai S, Bliden KP, Tantry US, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: chai s. Pharmacogenet Genomics. 2013 Jan;23(1):1-8. doi: 10.1097/FPC.0b013e32835aa8a2. Pharmacogenet Genomics. 2013. PMID: 23111421 Free PMC article.
Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel.
Gurbel PA, Bliden KP, Fort JG, Jeong YH, Shuldiner A, Chai S, Gesheff T, Antonino M, Gesheff M, Zhang Y, Tantry US. Gurbel PA, et al. Among authors: chai s. Am Heart J. 2013 Feb;165(2):176-82. doi: 10.1016/j.ahj.2012.07.032. Epub 2012 Dec 4. Am Heart J. 2013. PMID: 23351820 Clinical Trial.
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Albert JS, Yerges-Armstrong LM, Horenstein RB, Pollin TI, Sreenivasan UT, Chai S, Blaner WS, Snitker S, O'Connell JR, Gong DW, Breyer RJ 3rd, Ryan AS, McLenithan JC, Shuldiner AR, Sztalryd C, Damcott CM. Albert JS, et al. Among authors: chai s. N Engl J Med. 2014 Jun 12;370(24):2307-2315. doi: 10.1056/NEJMoa1315496. Epub 2014 May 21. N Engl J Med. 2014. PMID: 24848981 Free PMC article.
Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.
Yerges-Armstrong LM, Chai S, O'Connell JR, Curran JE, Blangero J, Mitchell BD, Shuldiner AR, Damcott CM. Yerges-Armstrong LM, et al. Among authors: chai s. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1295-9. doi: 10.1093/gerona/glv212. Epub 2016 Feb 19. J Gerontol A Biol Sci Med Sci. 2016. PMID: 26896383 Free PMC article.
1,442 results