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Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin.
Posthumadeboer J, van Egmond PW, Helder MN, de Menezes RX, Cleton-Jansen AM, Beliën JA, Verheul HM, van Royen BJ, Kaspers GJ, van Beusechem VW. Posthumadeboer J, et al. Among authors: van royen bj, van egmond pw, van beusechem vw. Oncotarget. 2012 Oct;3(10):1169-81. doi: 10.18632/oncotarget.600. Oncotarget. 2012. PMID: 23045411 Free PMC article.
Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
Kotov IN, Siebring-van Olst E, Knobel PA, van der Meulen-Muileman IH, Felley-Bosco E, van Beusechem VW, Smit EF, Stahel RA, Marti TM. Kotov IN, et al. Among authors: van der meulen muileman ih, van beusechem vw. Mol Oncol. 2014 Dec;8(8):1747-59. doi: 10.1016/j.molonc.2014.07.008. Epub 2014 Jul 22. Mol Oncol. 2014. PMID: 25113059 Free PMC article.
A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting.
Hodzic J, Dingjan I, Maas MJ, van der Meulen-Muileman IH, de Menezes RX, Heukelom S, Verheij M, Gerritsen WR, Geldof AA, van Triest B, van Beusechem VW. Hodzic J, et al. Among authors: van der meulen muileman ih, van triest b, van beusechem vw. Radiat Oncol. 2015 Feb 27;10:55. doi: 10.1186/s13014-015-0355-2. Radiat Oncol. 2015. PMID: 25888875 Free PMC article.
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF. de Lange J, et al. Among authors: van der meulen ih, van beusechem vw. Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399. Nat Commun. 2015. PMID: 26423134 Free PMC article.
The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics.
Martens-de Kemp SR, Brink A, van der Meulen IH, de Menezes RX, Te Beest DE, Leemans CR, van Beusechem VW, Braakhuis BJ, Brakenhoff RH. Martens-de Kemp SR, et al. Among authors: van der meulen ih, van beusechem vw. Mol Cancer Ther. 2017 Mar;16(3):540-550. doi: 10.1158/1535-7163.MCT-16-0457. Epub 2016 Dec 15. Mol Cancer Ther. 2017. PMID: 27980104
A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.
Siebring-van Olst E, Blijlevens M, de Menezes RX, van der Meulen-Muileman IH, Smit EF, van Beusechem VW. Siebring-van Olst E, et al. Among authors: van der meulen muileman ih, van beusechem vw. Mol Oncol. 2017 May;11(5):534-551. doi: 10.1002/1878-0261.12052. Epub 2017 Apr 11. Mol Oncol. 2017. PMID: 28296343 Free PMC article.
A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.
Amado-Azevedo J, Reinhard NR, van Bezu J, de Menezes RX, van Beusechem VW, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL. Amado-Azevedo J, et al. Among authors: van bezu j, van hinsbergh vwm, van beusechem vw, van nieuw amerongen gp. Sci Rep. 2017 Aug 31;7(1):10132. doi: 10.1038/s41598-017-10392-0. Sci Rep. 2017. PMID: 28860633 Free PMC article.
High-Throughput Firefly Luciferase Reporter Assays.
Siebring-van Olst E, van Beusechem VW. Siebring-van Olst E, et al. Among authors: van beusechem vw. Methods Mol Biol. 2018;1755:19-29. doi: 10.1007/978-1-4939-7724-6_2. Methods Mol Biol. 2018. PMID: 29671260
117 results