Krishnamoorthy J - Search Results

1

Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.

Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Krishnamoorthy J, et al. J Phys Chem B. 2012 Nov 26;116(46):13618-23. doi: 10.1021/jp305279w. Epub 2012 Nov 12. J Phys Chem B. 2012. PMID: 23116141 Free PMC article.

2

Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.

Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Suzuki Y, et al. Among authors: krishnamoorthy j. Biochemistry. 2013 Mar 19;52(11):1903-12. doi: 10.1021/bi400027y. Epub 2013 Mar 8. Biochemistry. 2013. PMID: 23445400 Free PMC article.

3

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide.

Brender JR, Krishnamoorthy J, Messina GM, Deb A, Vivekanandan S, La Rosa C, Penner-Hahn JE, Ramamoorthy A. Brender JR, et al. Among authors: krishnamoorthy j. Chem Commun (Camb). 2013 Apr 25;49(32):3339-41. doi: 10.1039/c3cc40383a. Chem Commun (Camb). 2013. PMID: 23505632

4

Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78).

Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lee DK, et al. Among authors: krishnamoorthy j. Biochemistry. 2013 May 14;52(19):3254-63. doi: 10.1021/bi400087n. Epub 2013 Apr 29. Biochemistry. 2013. PMID: 23590672 Free PMC article.

5

Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.

Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH. Lee S, et al. Among authors: krishnamoorthy j. J Am Chem Soc. 2014 Jan 8;136(1):299-310. doi: 10.1021/ja409801p. Epub 2013 Dec 27. J Am Chem Soc. 2014. PMID: 24397771 Free PMC article.

6

Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study.

Yesuvadian R, Krishnamoorthy J, Ramamoorthy A, Bhunia A. Yesuvadian R, et al. Among authors: krishnamoorthy j. Biochem Biophys Res Commun. 2014 May 16;447(4):590-5. doi: 10.1016/j.bbrc.2014.04.041. Epub 2014 Apr 18. Biochem Biophys Res Commun. 2014. PMID: 24747079

7

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species.

DeToma AS, Krishnamoorthy J, Nam Y, Lee HJ, Brender JR, Kochi A, Lee D, Onnis V, Congiu C, Manfredini S, Vertuani S, Balboni G, Ramamoorthy A, Lim MH. DeToma AS, et al. Among authors: krishnamoorthy j. Chem Sci. 2014 Dec 1;5(12):4851-4862. doi: 10.1039/c4sc01531b. Chem Sci. 2014. PMID: 25383163 Free PMC article.

8

Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP.

Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Brender JR, et al. Among authors: krishnamoorthy j. J Phys Chem B. 2015 Feb 19;119(7):2886-96. doi: 10.1021/jp511758w. Epub 2015 Feb 3. J Phys Chem B. 2015. PMID: 25645610 Free PMC article.

9

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification.

Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. Kotler SA, et al. Among authors: krishnamoorthy j. Sci Rep. 2015 Jul 3;5:11811. doi: 10.1038/srep11811. Sci Rep. 2015. PMID: 26138908 Free PMC article.

10

Binding Moiety Mapping by Saturation Transfer Difference NMR.

Brender JR, Krishnamoorthy J, Ghosh A, Bhunia A. Brender JR, et al. Among authors: krishnamoorthy j. Methods Mol Biol. 2018;1824:49-65. doi: 10.1007/978-1-4939-8630-9_4. Methods Mol Biol. 2018. PMID: 30039401

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