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Page 1
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Forsyth T, Kearney PC, Kim BG, Johnson HW, Aay N, Arcalas A, Brown DS, Chan V, Chen J, Du H, Epshteyn S, Galan AA, Huynh TP, Ibrahim MA, Kane B, Koltun ES, Mann G, Meyr LE, Lee MS, Lewis GL, Noguchi RT, Pack M, Ridgway BH, Shi X, Takeuchi CS, Zu P, Leahy JW, Nuss JM, Aoyama R, Engst S, Gendreau SB, Kassees R, Li J, Lin SH, Martini JF, Stout T, Tong P, Woolfrey J, Zhang W, Yu P. Forsyth T, et al. Among authors: leahy jw. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7653-8. doi: 10.1016/j.bmcl.2012.10.007. Epub 2012 Oct 16. Bioorg Med Chem Lett. 2012. PMID: 23127890
Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.
Folkes A, Brown SD, Canne LE, Chan J, Engelhardt E, Epshteyn S, Faint R, Golec J, Hanel A, Kearney P, Leahy JW, Mac M, Matthews D, Prisbylla MP, Sanderson J, Simon RJ, Tesfai Z, Vicker N, Wang S, Webb RR, Charlton P. Folkes A, et al. Among authors: leahy jw. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1063-6. doi: 10.1016/s0960-894x(02)00078-1. Bioorg Med Chem Lett. 2002. PMID: 11909718
Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.
Ibrahim MA, Johnson HW, Jeong JW, Lewis GL, Shi X, Noguchi RT, Williams M, Leahy JW, Nuss JM, Woolfrey J, Banica M, Bentzien F, Chou YC, Gibson A, Heald N, Lamb P, Mattheakis L, Matthews D, Shipway A, Wu X, Zhang W, Zhou S, Shankar G. Ibrahim MA, et al. Among authors: leahy jw. J Med Chem. 2012 Feb 9;55(3):1368-81. doi: 10.1021/jm201533b. Epub 2012 Jan 24. J Med Chem. 2012. PMID: 22214363
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors.
Leahy JW, Buhr CA, Johnson HW, Kim BG, Baik T, Cannoy J, Forsyth TP, Jeong JW, Lee MS, Ma S, Noson K, Wang L, Williams M, Nuss JM, Brooks E, Foster P, Goon L, Heald N, Holst C, Jaeger C, Lam S, Lougheed J, Nguyen L, Plonowski A, Song J, Stout T, Wu X, Yakes MF, Yu P, Zhang W, Lamb P, Raeber O. Leahy JW, et al. J Med Chem. 2012 Jun 14;55(11):5467-82. doi: 10.1021/jm300403a. Epub 2012 May 17. J Med Chem. 2012. PMID: 22548342
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
Takeuchi CS, Kim BG, Blazey CM, Ma S, Johnson HW, Anand NK, Arcalas A, Baik TG, Buhr CA, Cannoy J, Epshteyn S, Joshi A, Lara K, Lee MS, Wang L, Leahy JW, Nuss JM, Aay N, Aoyama R, Foster P, Lee J, Lehoux I, Munagala N, Plonowski A, Rajan S, Woolfrey J, Yamaguchi K, Lamb P, Miller N. Takeuchi CS, et al. Among authors: leahy jw. J Med Chem. 2013 Mar 28;56(6):2218-34. doi: 10.1021/jm3007933. Epub 2013 Mar 7. J Med Chem. 2013. PMID: 23394126
Synthesis and Activity of a New Series of Antileishmanial Agents.
Kanwar A, Eduful BJ, Barbeto L, Carletti Bonomo P, Lemus A, Vesely BA, Mutka TS, Azhari A, Kyle DE, Leahy JW. Kanwar A, et al. Among authors: leahy jw. ACS Med Chem Lett. 2017 Jul 31;8(8):797-801. doi: 10.1021/acsmedchemlett.7b00039. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835791 Free PMC article.
Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.
Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Dempsey DR, et al. Among authors: leahy jw. Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6. Sci Rep. 2017. PMID: 29044148 Free PMC article.
Binding-based proteomic profiling and the fatty acid amides.
Merkler DJ, Leahy JW. Merkler DJ, et al. Among authors: leahy jw. Trends Res. 2018 Nov;1(4):10.15761/TR.1000120. doi: 10.15761/TR.1000120. Epub 2018 Nov 12. Trends Res. 2018. PMID: 30775690 Free PMC article.
23 results