Wang Z - Search Results

1

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: wang z. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

2

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Duan H, Zheng J, Lai Q, Liu Z, Tian G, Wang Z, Li J, Shen J. Duan H, et al. Among authors: wang z. Bioorg Med Chem Lett. 2009 May 15;19(10):2777-9. doi: 10.1016/j.bmcl.2009.03.125. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19375311

3

Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity.

Chen Z, Tian G, Wang Z, Jiang H, Shen J, Zhu W. Chen Z, et al. Among authors: wang z. J Chem Inf Model. 2010 Apr 26;50(4):615-25. doi: 10.1021/ci9004173. J Chem Inf Model. 2010. PMID: 20353193

4

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors.

Xu Z, Liu Z, Chen T, Chen T, Wang Z, Tian G, Shi J, Wang X, Lu Y, Yan X, Wang G, Jiang H, Chen K, Wang S, Xu Y, Shen J, Zhu W. Xu Z, et al. Among authors: wang x, wang g, wang z, wang s. J Med Chem. 2011 Aug 11;54(15):5607-11. doi: 10.1021/jm200644r. Epub 2011 Jul 14. J Med Chem. 2011. PMID: 21714539

5

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.

Mao Y, Zhu W, Kong X, Wang Z, Xie H, Ding J, Terrett NK, Shen J, Shen J. Mao Y, et al. Among authors: wang z. Bioorg Med Chem. 2013 Jun 1;21(11):3090-104. doi: 10.1016/j.bmc.2013.03.053. Epub 2013 Apr 1. Bioorg Med Chem. 2013. PMID: 23602524

6

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: wang g, wang z. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

7

The selectivity and potency of the new PDE5 inhibitor TPN729MA.

Wang Z, Zhu D, Yang X, Li J, Jiang X, Tian G, Terrett NK, Jin J, Wu H, He Q, Yang B, Shen J. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7. doi: 10.1111/jsm.12285. Epub 2013 Aug 12. J Sex Med. 2013. PMID: 23937247

8

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.

Ren J, He Y, Chen W, Chen T, Wang G, Wang Z, Xu Z, Luo X, Zhu W, Jiang H, Shen J, Xu Y. Ren J, et al. Among authors: wang g, wang z. J Med Chem. 2014 Apr 24;57(8):3588-93. doi: 10.1021/jm5002315. Epub 2014 Apr 15. J Med Chem. 2014. PMID: 24702184

9

Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.

Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y. Li Z, et al. Among authors: wang j, wang z. Eur J Med Chem. 2014 Nov 24;87:346-63. doi: 10.1016/j.ejmech.2014.09.078. Epub 2014 Sep 28. Eur J Med Chem. 2014. PMID: 25277067

10

Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors.

Jiang T, Zhou Y, Zhu J, Chen Z, Sun P, Zhang Q, Wang Z, Shao Q, Jiang X, Li B, Wang H, Zhu W, Shen J. Jiang T, et al. Among authors: wang h, wang z. Arch Pharm (Weinheim). 2015 Jun;348(6):399-407. doi: 10.1002/ardp.201500082. Epub 2015 Apr 14. Arch Pharm (Weinheim). 2015. PMID: 25871012

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