Oka S - Search Results

1

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.

Sheng Z, Oka S, Tsuchimoto D, Abolhassani N, Nomaru H, Sakumi K, Yamada H, Nakabeppu Y. Sheng Z, et al. Among authors: oka s. J Clin Invest. 2012 Dec;122(12):4344-61. doi: 10.1172/JCI65053. Epub 2012 Nov 12. J Clin Invest. 2012. PMID: 23143307 Free PMC article.

2

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.

Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y. Ichikawa J, et al. Among authors: oka s. DNA Repair (Amst). 2008 Mar 1;7(3):418-30. doi: 10.1016/j.dnarep.2007.11.007. Epub 2007 Dec 21. DNA Repair (Amst). 2008. PMID: 18155646

3

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y. Oka S, et al. EMBO J. 2008 Jan 23;27(2):421-32. doi: 10.1038/sj.emboj.7601975. Epub 2008 Jan 10. EMBO J. 2008. PMID: 18188152 Free PMC article.

4

Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.

Ohno M, Oka S, Nakabeppu Y. Ohno M, et al. Among authors: oka s. Methods Mol Biol. 2009;554:199-212. doi: 10.1007/978-1-59745-521-3_13. Methods Mol Biol. 2009. PMID: 19513676

5

Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage.

Oka S, Ohno M, Nakabeppu Y. Oka S, et al. Methods Mol Biol. 2009;554:251-64. doi: 10.1007/978-1-59745-521-3_16. Methods Mol Biol. 2009. PMID: 19513679

6

Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.

Nakabeppu Y, Oka S, Sheng Z, Tsuchimoto D, Sakumi K. Nakabeppu Y, et al. Among authors: oka s. Mutat Res. 2010 Nov 28;703(1):51-8. doi: 10.1016/j.mrgentox.2010.06.006. Epub 2010 Jun 11. Mutat Res. 2010. PMID: 20542142 Free article. Review.

7

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.

Oka S, Nakabeppu Y. Oka S, et al. Cancer Sci. 2011 Apr;102(4):677-82. doi: 10.1111/j.1349-7006.2011.01869.x. Epub 2011 Feb 17. Cancer Sci. 2011. PMID: 21235684 Free article. Review.

8

8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.

Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y. Leon J, et al. Among authors: oka s. Sci Rep. 2016 Feb 25;6:22086. doi: 10.1038/srep22086. Sci Rep. 2016. PMID: 26912170 Free PMC article.

9

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.

Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y. Abolhassani N, et al. Among authors: oka s. Mech Ageing Dev. 2017 Jan;161(Pt A):95-104. doi: 10.1016/j.mad.2016.05.005. Epub 2016 May 24. Mech Ageing Dev. 2017. PMID: 27233446 Review.

10

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.

Oka S, Leon J, Sakumi K, Abolhassani N, Sheng Z, Tsuchimoto D, LaFerla FM, Nakabeppu Y. Oka S, et al. Sci Rep. 2021 Mar 23;11(1):5819. doi: 10.1038/s41598-021-84640-9. Sci Rep. 2021. PMID: 33758207 Free PMC article.

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