Conn PM - Search Results

1

Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target.

Maya-Núñez G, Ulloa-Aguirre A, Janovick JA, Conn PM. Maya-Núñez G, et al. Among authors: conn pm. Subcell Biochem. 2012;63:263-89. doi: 10.1007/978-94-007-4765-4_14. Subcell Biochem. 2012. PMID: 23161143 Review.

2

Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization.

Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB, Conn PM. Brothers SP, et al. Among authors: conn pm. Mol Cell Endocrinol. 2002 Apr 25;190(1-2):19-27. doi: 10.1016/s0303-7207(02)00040-0. Mol Cell Endocrinol. 2002. PMID: 11997175

3

Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target.

Janovick JA, Maya-Nunez G, Conn PM. Janovick JA, et al. Among authors: conn pm. J Clin Endocrinol Metab. 2002 Jul;87(7):3255-62. doi: 10.1210/jcem.87.7.8582. J Clin Endocrinol Metab. 2002. PMID: 12107234

4

Protein origami: therapeutic rescue of misfolded gene products.

Conn PM, Leaños-Miranda A, Janovick JA. Conn PM, et al. Mol Interv. 2002 Sep;2(5):308-16. doi: 10.1124/mi.2.5.308. Mol Interv. 2002. PMID: 14993385 Review.

5

Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect.

Brothers SP, Cornea A, Janovick JA, Conn PM. Brothers SP, et al. Among authors: conn pm. Mol Endocrinol. 2004 Jul;18(7):1787-97. doi: 10.1210/me.2004-0091. Epub 2004 Apr 22. Mol Endocrinol. 2004. PMID: 15105440

6

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.

Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Ulloa-Aguirre A, et al. Among authors: conn pm. Traffic. 2004 Nov;5(11):821-37. doi: 10.1111/j.1600-0854.2004.00232.x. Traffic. 2004. PMID: 15479448 Free article. Review.

7

Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants.

Knollman PE, Janovick JA, Brothers SP, Conn PM. Knollman PE, et al. Among authors: conn pm. J Biol Chem. 2005 Jul 1;280(26):24506-14. doi: 10.1074/jbc.M501978200. Epub 2005 May 10. J Biol Chem. 2005. PMID: 15886197 Free article.

8

Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor.

Conn PM, Knollman PE, Brothers SP, Janovick JA. Conn PM, et al. Mol Endocrinol. 2006 Dec;20(12):3035-41. doi: 10.1210/me.2006-0066. Epub 2006 Mar 23. Mol Endocrinol. 2006. PMID: 16556733 Review.

9

'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation.

Conn PM, Janovick JA, Brothers SP, Knollman PE. Conn PM, et al. J Endocrinol. 2006 Jul;190(1):13-6. doi: 10.1677/joe.1.06771. J Endocrinol. 2006. PMID: 16837606

10

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease.

Ulloa-Aguirre A, Janovick JA, Miranda AL, Conn PM. Ulloa-Aguirre A, et al. Among authors: conn pm. ACS Chem Biol. 2006 Nov 21;1(10):631-8. doi: 10.1021/cb600360h. ACS Chem Biol. 2006. PMID: 17168568 Review.

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